文献类型：期刊文献

英文题名：Preparation, characterization, in vitro bioactivity and rBMSCs responses to tantalum pentoxide/polyimide biocomposites for dental and orthopedic implants

作者：Asadullah, Syed[1,4];Wu, Han[1];Mei, Shiqi[1];Wang, Deqiang[1];Pan, Yongkang[1];Wang, Dongliang[2];Zhao, Jun[3];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Orthoped Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Res Inst Stomatol, Peoples Hosp 9, Shanghai Key Lab Stomatol,Dept Orthodont,Sch Med, Shanghai 200011, Peoples R China;[4]Univ Lahore, Dept Phys, Lahore, Pakistan

年份：2019

卷号：177

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20193707435217);WOS:【SCI-EXPANDED(收录号:WOS:000494052600070)】；

基金：The grants were from the National Key Research and Development Program (2016YFC1102100), the National Natural Science Foundation of China (81771990) and Key Medical Program of Science and Technology Development of Shanghai (19441906100, 17441900600 and 17441902000).

语种：英文

外文关键词：Tantalum pentoxide; Polyimide; Bioactive composite; Surface properties; Cytocompatibility

摘要：Polyimide (PI) may become a promising biomaterial for dental and orthopedic application due to its high mechanical strength, good biocompatibility and bio-stability as well as modulus of elasticity similar to the bone of human body. In this study, bioactive tantalum pentoxide (Ta2O5, TO)/polyimide (PI) composites (TPC) were fabricated by blending modification through a process of cold-pressing and sintering. The results revealed that the compressive strength, thermal stability, surface roughness, hydrophilicity and surface energy of TPC were significantly enhanced with the increase of TO content. Moreover, apatite mineralization of TPC in simulated body fluid (SBF) was obviously improved, in which TPC with TO of 50 wt% content (TPC50) displayed the best bioactivity. Furthermore, the cellular responses (adhesion, proliferation and differentiation) of rat bone mesenchymal stem cells (rBMSCs) to TPC were obviously upregulated with the increase of TO content. The results demonstrated that the TO content in the composites remarkably affected not only physical-chemical properties but also the cells behaviors. It can be suggested that TPC50 with improved surface properties and bioactivity as well as good cytocompatibility would have great potential and prospect for dental and orthopedic applications.