文献类型：期刊文献

英文题名：Micelles/sodium-alginate composite gel beads: A new matrix for oral drug delivery of indomethacin

作者：Huang, Xiujuan[1];Xiao, Yan[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2012

卷号：87

期号：1

起止页码：790

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20114314447589);WOS:【SCI-EXPANDED(收录号:WOS:000297389000105)】；

基金：This research was supported by the Fundamental Research Funds for the Central Universities (WD0913008 and WD1014017), the Natural Science Foundation of Shanghai (11ZR1409200), "Shu Guang" Project of Shanghai Municipal Education Commission, Shanghai Leading Academic Discipline Project (B502), Shanghai Key Laboratory Project (08DZ2230500), and Changjiang Scholars and Innovative Research Team in University (IRT0825).

语种：英文

外文关键词：Sodium-alginate bead; Micelle; Drug release; Composite; Oral delivery

摘要：Micelles/sodium-alginate composite gel beads (micelles/SA beads) were constructed from SA matrix and indomethacin (IND) loaded six-arm block copolymer poly(epsilon-caprolactone)-block-(dimethylamino)ethyl methacrylate (S(PCL-b-PDMA)(6)) micelles. The morphology, swelling property and drug loading level of the beads were investigated. The release behavior of IND from three matrices including micelles, SA beads and micelles/SA beads was evaluated at pH 1.2, 6.8 and 7.4, as well as in the simulated gastrointestinal (GI) tract. Significant differences in the release of IND from each matrix were observed in the acidic and near neutral pH fluids. The results suggested that IND could be protected by the micelles/SA beads from being released under acidic conditions in the stomach and would be mainly delivered to the small intestine and the colon. The release behavior was dependent on the initial concentrations of SA and calcium chloride (CaCl2) due to the different crosslinking densities. The results demonstrated that these micelles/SA beads could represent a promising oral drug delivery system for drugs with poor water solubility. (C) 2011 Elsevier Ltd. All rights reserved.