文献类型：期刊文献

英文题名：Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo

作者：Jiang, Weinan[1,2,3];Xiao, Ximian[1,2,3];Wu, Yueming[1,2,3];Zhang, Weiwei[1,2,3];Cong, Zihao[1,2,3];Liu, Jingjing[1,2,3];Chen, Sheng[1,2,3];Zhang, Haodong[1,2,3];Xie, Jiayang[1,2,3];Deng, Shuai[1,2,3];Chen, Minzhang[1,2,3];Wang, Yun[4];Shao, Xiaoyan[4];Dai, Yidong[4];Sun, Yun[4];Fei, Jian[5];Liu, Runhui[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[4]Shanghai Ruijin Rehabil Hosp, Shanghai 200023, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gen Surg, Shanghai 200025, Peoples R China

年份：2020

卷号：8

期号：2

起止页码：739

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20200508105885);WOS:【SCI-EXPANDED(收录号:WOS:000509549500016)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 21574038, 21774031, 21861162010), the Natural Science Foundation of Shanghai (18ZR1410300), the National Key Research and Development Program of China (2016YFC1100401), the "Eastern Scholar Professorship" from Shanghai Local Government (TP2014034), the national special fund for State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (22221818014, 50321041917001), the Key Laboratory of Specially Functional Polymeric Materials and Related Technology (ECUST) of Ministry of Education, Shanghai Municipal Science and Technology Commission (17441901000), The Medical Cross Fund Project of SJTU (YG2019ZDA17). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Antimicrobial agents - Bacteria - Antibiotics - Lithium compounds - Network security

摘要：Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring resistance to common antibiotics. There is an urgent need to develop antimicrobial agents against MDR Pseudomonas aeruginosa. Here we report a 27-mer peptide polymer 90 : 10 DLL : BLG, as a synthetic mimic of a host defense peptide, that displayed potent in vitro and in vivo activities against multiple strains of clinically isolated MDR Pseudomonas aeruginosa, performing even better than antibiotics within our study. This peptide polymer also showed negligible hemolysis and low cytotoxicity, as well as quick bacterial killing efficacy. The structural diversity of peptide polymers, their easy synthesis from lithium hexamethyldisilazide-initiated fast N-carboxyanhydride polymerization, and the excellent reproducibility of their chemical structure and biological profiles altogether suggested great potential for antimicrobial applications of peptide polymers as synthetic mimics of host defense peptides.