文献类型：期刊文献

英文题名：The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release

作者：Zhang, Yue[1,2];Gao, Jungang[1];Zheng, Hetang[2];Zhang, Ran[3];Han, Yucui[2]

机构：[1]Hebei Univ, Coll Chem & Envirom Sci, Baoding 071002, Peoples R China;[2]Hebei Univ Sci & Technol, Sch Chem & Pharmaceut Engn, Shijiazhuang, Peoples R China;[3]E China Univ Sci & Technol, Coll Chem Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：6

起止页码：649

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289073800001)】；

语种：英文

外文关键词：nanoemulsion; 3,5-dihydroxy-4-isopropylstilbene; DHPS; pseudo-ternary phase diagram

摘要：We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 mu g . cm(-2) to 273.15 mu g . cm(-2)) and could become a favorable new dosage form for DHPS.