文献类型：期刊文献

英文题名：A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO2

作者：Liu, Chaoyang[1,2,3];Sun, Haozhou[1,2,3];Qin, Cheng[1,2,3];Yang, Tiannuo[1,2,3];Zhang, Wenxian[1,2,3];Zhou, Yuan[1,2,3];Li, Yani[1,2,3];Jia, Zheng Robert[4];Chu, Changhu[1,2,3]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]Shanghai High Sch, Int Div, 989 Baise Rd, Shanghai 200231, Peoples R China

年份：2022

卷号：33

期号：10

起止页码：993

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000790981400001)，CCR-EXPANDED(收录号:WOS:000790981400001)】；

基金：We are thankful for the support of the National Natural Science Foundation of China (21372081, 21172072).

语种：英文

外文关键词：amine oxidation; sodium chlorite; transition-metal-free; carbon dioxide; pH adjustment

摘要：By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.