文献类型：期刊文献

英文题名：Unexpectedly Enhanced Solubility of Aromatic Amino Acids and Peptides in an Aqueous Solution of Divalent Transition-Metal Cations

作者：Shi, Guosheng[1,2];Dang, Yaru[1,2,3];Pan, Tingting[1,2,3];Liu, Xing[1,2];Liu, Hui[1,2,3];Li, Shaoxian[1,2,4,5];Zhang, Lijuan[6];Zhao, Hongwei[1,2];Li, Shaoping[3];Han, Jiaguang[4,5];Tai, Renzhong[6];Zhu, Yiming[7];Li, Jichen[8];Ji, Qing[9];Mole, R. A.[10];Yu, Dehong[10];Fang, Haiping[1,2]

机构：[1]Chinese Acad Sci, Div Interfacial Water, Shanghai 201800, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[4]Tianjin Univ, Ctr Terahertz Waves, Tianjin 300072, Peoples R China;[5]Tianjin Univ, Coll Precis Instrument & Optoelect Engn, Tianjin 300072, Peoples R China;[6]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China;[7]Univ Shanghai Sci & Technol, Shanghai Key Lab Modern Opt Syst, 516 Jungong Rd, Shanghai 200093, Peoples R China;[8]Univ Manchester, Sch Phys & Astron, Manchester M13 9PL, Lancs, England;[9]Hebei Univ Technol, Inst Biophys, Tianjin 300401, Peoples R China;[10]Australian Nucl Sci & Technol Org, Lucas Heights, NSW 2234, Australia

年份：2016

卷号：117

期号：23

外文期刊名：PHYSICAL REVIEW LETTERS

收录：;EI(收录号：20164903091038);WOS:【SCI-EXPANDED(收录号:WOS:000389032600016)】；

基金：We thank Yi Gao, Guanghong Wei, Jun Hu, Yusong Tu, Rongzheng Wan, and Garry Mcintyre for their constructive suggestions and helpful discussion. This work was supported by the National Natural Science Foundation of China (Grants No. 11574339, 11404361, 11290164, 11290165 and 61422509), the National Basic Research Program of China (Grant No. 2014CB339800), the Key Research Program of the Chinese Academy of Sciences (Grant No. KJZD-EW-M03), the Deepcomp7000 and ScGrid of Supercomputing Center, Computer Network Information Center of Chinese Academy of Sciences, the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase), and the Shanghai Supercomputer Center of China. We also thank the beam line 08U1A of the Shanghai Synchrotron Radiation Facilities (SSRF) for the measurements of XANES near the Cu L edge, and the Australian Centre for Neutron Scattering, ANSTO, for access to neutron scattering facilities, and for providing technical support for the QENS measurements (P3930).

语种：英文

外文关键词：Solubility - Aromatization - Positive ions - Chlorine compounds - Amino acids - Copper compounds - Aromatic compounds - Solutions - Transition metals

摘要：We experimentally observed considerable solubility of tryptophan (Trp) in a CuCl2 aqueous solution, which could reach 2-5 times the solubility of Trp in pure water. Theoretical studies show that the strong cation-p interaction between Cu2+ and the aromatic ring in Trp modifies the electronic distribution of the aromatic ring to enhance significantly the water affinity of Trp. Similar solubility enhancement has also been observed for other divalent transition-metal cations (e.g., Zn2+ and Ni2+), another aromatic amino acid (phenylalanine), and three aromatic peptides (Trp-Phe, Phe-Phe, and Trp-Ala-Phe).