文献类型：期刊文献

英文题名：Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein

作者：Zheng, Yuanhong[1,2];Zou, Fangyuan[1,2];Wang, Jingjing[1,2];Yin, Guifang[1,2];Le, Vanminh[1,2];Fei, Zhewei[3];Liu, Jianwen[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, Sch Pharm,Dept Mol & Cellular Pharmacol, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg,Chongming Branch, Chengqiaozhen 202150, Chongming Shang, Peoples R China

年份：2015

卷号：290

期号：14

起止页码：8975

外文期刊名：JOURNAL OF BIOLOGICAL CHEMISTRY

收录：;EI(收录号：20151500733491);WOS:【SCI-EXPANDED(收录号:WOS:000352207100024)】；

基金：This work was supported by Shanghai Committee of Science and Technology Grants 13140902300 and 11DZ2260600.

语种：英文

外文关键词：Cell signaling - Cells - Diseases - Vaccines - Cytology - Tumors

摘要：Like most of the strategies for cancer immunotherapy, photodynamic therapy-mediated vaccination has shown poor clinical outcomes in application. The aim of this study is to offer a glimpse at the mechanisms that are responsible for the failure based on cancer immuno-editing theory and to search for a positive solution. In this study we found that tumor cells were able to adapt themselves to the immune pressure exerted by vaccination. The survived tumor cells exhibited enhanced tumorigenic and stem-like phenotypes as well as undermined immunogenicity. Viewed as a whole, immune-selected tumor cells showed more malignant characteristics and the ability of immune escape, which might contribute to the eventual relapse. Thrombospondin-1 signaling via CD47 helped prevent tumor cells from becoming stem-like and rendered them vulnerable to immune attack. These findings prove that the TSP-1/CD47/SIRP-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 as a key signal with therapeutic benefits in overcoming long term relapse, providing new evidence for the clinical promise of cancer vaccination.