文献类型：期刊文献

英文题名：From Spontaneous to Photo-triggered and Photo-calibrated Nitric Oxide Donors

作者：Zhang, Ziqian[1];Luo, Xiao[2];Yang, Youjun[3]

机构：[1]Guangxi Univ Chinese Med, Guangxi Sci Res Ctr Tradit Chinese Med, Wuhe Ave 13, Nanning 530200, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Dongchuan Rd 500, Shanghai 200241, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2021

卷号：61

期号：3-4

起止页码：159

外文期刊名：ISRAEL JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000592468200001)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 21822805, 22078098, 21908032 and 21908065), the Commission of Science and Technology of Shanghai Municipality (18430711000), Guangxi Natural Science Foundation Program (2018GXNSFBA281194), China Post-doctoral Science Foundation (No. 2019M651427, 2020T130197).

语种：英文

外文关键词：Nitric oxide; Nitric oxide donor; Photo-triggered; Photo-calibrated; Fluorescence

摘要：NO donors have found wide medical use long before the biorelevance of nitric oxide (NO) was unveiled. From glyceryl trinitrate, amyl nitrite and nitroprusside, to nitrosothiols, NONOates and more, a wide variety of chemicals have been employed as nitric oxide donors for treating pathological conditions and investigating the NO biology. Yet, the release kinetics of these classic NO donors are hard-to-define and hard-to-monitor in biological milieu. Novel NO donors with robustly defined NO release profiles are sought after. These endeavours have introduced a plethora of novel NO donors, including stimulus-triggered NO donors, fluorophore-labeled NO donors. The field also sees a recent addition, i. e. photo-triggered and photo-calibrated NO donors, whose NO release is photo-controlled and further accompanied by a fluorescence turn-on as a built-in calibration mechanism of NO release. This review provides an overview of the NO biochemistry, as a roadmap for the chemistry of NO donors. The design rationale and the release mechanism of different classes of NO donors were discussed. Some interesting and notable applications were briefly discussed, e. g. super-resolution localization microscopic imaging of cell structures, and photo-acoustic probes for disease diagnosis. With joint-force, these NO donors constitutes a group of indispensable molecular tools of chemical biology and medicine in real applications.