文献类型：期刊文献

英文题名：Enantioselective Direct Mannich Reactions of Cyclic β-Ketoesters Catalyzed by Chiral Phosphine via a Novel Dual-Reagent Catalysis

作者：Lou, Yan-Peng[1];Zheng, Chang-Wu[2];Pan, Ren-Ming[2];Jin, Qiao-Wen[2];Zhao, Gang[2];Li, Zhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

年份：2015

卷号：17

期号：3

起止页码：688

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000349274200075)，CCR-EXPANDED(收录号:WOS:000349274200075)】；

基金：Financial support from the National High Technology Research and Development Program of China (863 Program, 2011AA10A207) and the National Natural Science Foundation of China (Nos. 21472046, 21272247, 21290184) is gratefully acknowledged.

语种：英文

摘要：A combination of an amino acid derived chiral phosphine catalyst and methyl acrylate efficiently catalyzed the direct Mannich reaction of cyclic beta-ketoesters and N-Boc-aldimines. The dual-reagent catalysis was presumed to function through the formation of a zwitterion, which catalyzed the reaction with excellent stereocontrol via a hydrogen-bonding assisted chiral ion-pair pathway.