文献类型：期刊文献

英文题名：Fluorescent glycoprobes: a sweet addition for improved sensing

作者：He, Xiao-Peng[1,2];Zang, Yi[3];James, Tony D.[4];Li, Jia[3];Chen, Guo-Rong[1,2];Xie, Juan[5]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[5]Univ Paris Saclay, CNRS UMR 8531, PPSM, ENS Cachan, 61 Av President Wilson, F-94230 Cachan, France

年份：2017

卷号：53

期号：1

起止页码：82

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000391607100005)】；

基金：We warmly thank our collaborators and students who have contributed significantly to the papers featured in this article. Professor He Tian from ECUST is thanked for his tremendous support of our research. This research is supported by the 973 project (2013CB733700), the Science and Technology Commission of Shanghai Municipality (15540723800), the National Natural Science Foundation of China (21572058, 21576088) and the Shanghai Rising-Star Program (16QA1401400) (X.-P.H.). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. T.D.J. and J.X. thank ECUST for guest professorships.

语种：英文

摘要：The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and in vivo imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability to target specific tissues. Because of the enhanced water solubility, biocompatibility and targeting ability for specific cells, there has been an emerging movement to use carbohydrates as either the backbone or as a warhead to decorate conventional fluorescent probes, producing "glycoprobes'' with enhanced properties. This feature article provides an overview of recently developed glycoprobes for ion and protein detection as well as targeted (receptor targeting) cellular imaging and theranostics. Here, we summarise the tactics for preparing small molecular glycoprobes and their supramolecular 2D material composites.