文献类型：期刊文献

英文题名：Remarkable antibacterial activity of reduced graphene oxide functionalized by copper ions

作者：Tu, Yusong[1,2]; Li, Pei[3]; Sun, Jiajia[1]; Jiang, Jie[4]; Dai, Fangfang[5]; Wu, Yuanyan[1]; Chen, Liang[5]; Shi, Guosheng[6]; Tan, Yanwen[3]; Fang, Haiping[4,7]

机构：[1] College of Physics Science and Technology, Yangzhou University Jiangsu, 225009, China; [2] Key Laboratory of Polar Materials and Devices Ministry of Education, School of Physics and Electrical Science, East China Normal University, Shanghai, 200241, China; [3] State Key Laboratory of Surface Physics, Multiscale Research Institute of Complex Systems, Department of Physics, Fudan University, Shanghai, 200433, China; [4] Division of Interfacial Water, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; [5] Department of Optical Engineering, Zhejiang A&F University, Lin'an, 311300, China; [6] Shanghai Applied Radiation Institute, Shanghai University, Shanghai, 200444, China; [7] School of Science, East China University of Science and Technology, Shanghai, 200237, China

年份：2020

外文期刊名：arXiv

收录：EI(收录号：20200601230)

语种：英文

外文关键词：Cells - Copper - Cytology - Graphene oxide - Hazards - Mammals - Positive ions - Toxicity

摘要：Despite long-term efforts for exploring antibacterial agents or drugs, it remains challenging how to potentiate antibacterial activity and meanwhile minimize toxicity hazards to the environment. Here, we experimentally show that the functionality of reduced graphene oxide (rGO) through copper ions displays selective antibacterial activity significantly stronger than that of rGO itself and no toxicity to mammalian cells. Remarkably, this antibacterial activity is two orders of magnitude greater than the activity of its surrounding copper ions. We demonstrate that the rGO is functionalized through the cation–π interaction to massively adsorb copper ions to form a rGO–copper composite in solution and result in an extremely low concentration level of surrounding copper ions (less than ~0.5 μM). These copper ions on rGO are positively charged and strongly interact with negatively charged bacterial cells to selectively achieve antibacterial activity, while rGO exhibits the functionality to not only actuate rapid delivery of copper ions and massive assembly onto bacterial cells but also result in the valence shift in the copper ions from Cu2+ into Cu+ which greatly enhances the antibacterial activity. Notably, this functionality of rGO through cation–π interaction with copper ions can similarly achieve algaecidal activity but does not exert cytotoxicity against neutrally charged mammalian cells. The remarkable selective antibacterial activity from the rGO functionality as well as the inherent broad-spectrum-antibacterial physical mechanism represents a significant step toward the development of a novel antibacterial material and reagent without environmental hazards for practical application. Copyright ? 2020, The Authors. All rights reserved.