文献类型：期刊文献

英文题名：Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel-Crafts alkylation reaction of pyrroles

作者：Zhang, Jun-Wei[1,2];Liu, Xiao-Wei[1];Gu, Qing[1];Shi, Xiao-Xin[2];You, Shu-Li[1,2]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：2

期号：5

起止页码：476

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806136241);WOS:【SCI-EXPANDED(收录号:WOS:000364445300004)】；

基金：We thank the National Basic Research Program of China (973 Program 2015CB856600) and the National Natural Science Foundation of China (21272253, 21332009, 21361140373, 21421091) for generous financial support.

语种：英文

外文关键词：Alkylation - Olefins

摘要：A sequential catalysis involving olefin cross-metathesis/asymmetric intramolecular Friedel-Crafts alkylation of pyrrole derivatives has been developed. A variety of enantioenriched 4,5,6,7-tetrahydroindoles were obtained in good yields and enantioselectivity by combining a Zhan-1B catalyst with a chiral phosphoric acid.