文献类型：期刊文献

英文题名：Synthesis of Amphiphilic Block Polyphosphoester and Exploring Its Potential in Reduction-Responsive Drug Release

作者：Li, Jinjin[1,2]; Chen, Xudong[1]; Jiang, Jie[1]; Zhao, Ling[1,2]; Xi, Zhenhao[1,2]

机构：[1] State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2024

卷号：6

期号：1

起止页码：693

外文期刊名：ACS Applied Polymer Materials

收录：EI(收录号：20235115255310)

语种：英文

外文关键词：Biocompatibility - Controlled drug delivery - Drug products - Nanoparticles - Ring opening polymerization - Targeted drug delivery - Tumors

摘要：In this work, a reduction-responsive amphiphilic block polyphosphoester was synthesized via one-pot sequential organocatalytic ring-opening polymerization of 2-butoxy-1,3,2-dioxaphospholane 2-oxide (BEP) and 2-(but-3-en-1-yloxy)-1,3,2-dioxaphospholane 2-oxide (BenEP), followed by postpolymerization modification through click reaction with 2-mercaptoethanol and esterification with dithiodipropionic anhydride, respectively. The as-prepared PBEP-b-PBenEP-SS-COOH, abbreviated as PBBS, can self-assemble into well-dispersed spherical nanoparticles with an average size of about 75 nm in aqueous solution, and the nanoparticles exhibit glutathione (GSH)-triggered disassembly, which can be a promising antitumor drug carrier. Paclitaxel (PTX) encapsulation and in vitro responsive release results confirm that the PTX-loaded PBBS nanoparticles (PTX@PBBS) with drug loading content of 4.3% have an increased average size of 138 nm and exhibit a promising drug release feature with approximately 80% of PTX within 24 h incubation in the medium with 10 mM GSH. In addition, both cytotoxicity and intracellular uptake investigations demonstrate that the PBBS nanoparticles have a good biocompatibility, while PTX@PBBS can be internalized by tumor cells and efficiently release the anticancer drug PTX to inhibit the proliferation of tumor cells. ? 2023 American Chemical Society.