文献类型：期刊文献

英文题名：AMP-Conjugated Quantum Dots: Low Immunotoxicity Both In Vitro and In Vivo

作者：Dai, Tongcheng[1];Li, Na[1];Liu, Lu[3];Liu, Qin[1,2];Zhang, Yuanxing[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China;[3]Univ Shanghai Sci & Technol, Coll Sci, Dept Chem, Shanghai 200093, Peoples R China

年份：2015

卷号：10

期号：1

起止页码：1

外文期刊名：NANOSCALE RESEARCH LETTERS

收录：;EI(收录号：20154601544048);WOS:【SCI-EXPANDED(收录号:WOS:000369815000001)】；

基金：The authors would like to thank Professor Xinhua Zhong for providing the oil phase CdSe/CdS/ZnS QDs. This work was supported by the National Special Fund for State Key Laboratory of Bioreactor Engineering, Grant No. 2060204.

语种：英文

外文关键词：AMP; Quantum dots; Immunotoxicity; In vivo

摘要：Quantum dots (QDs) are engineered nanoparticles that possess special optical and electronic properties and have shown great promise for future biomedical applications. In this work, adenosine 5'-monophosphate (AMP), a small biocompatible molecular, was conjugated to organic QDs to produce hydrophilic AMP-QDs. Using macrophage J774A. 1 as the cell model, AMP-QDs exhibited both prior imaging property and low toxicity, and more importantly, triggered limited innate immune responses in macrophage, indicating low immunotoxicity in vitro. Using BALB/c mice as the animal model, AMP-QDs were found to be detained in immune organs but did not evoke robust inflammation responses or obvious histopathological abnormalities, which reveals low immunotoxicity in vivo. This work suggests that AMP is an excellent surface ligand with low immunotoxicity, and potentially used in surface modification for more extensive nanoparticles.