文献类型：期刊文献

英文题名：Delayed but not loss of gliogenesis in Rbpj-deficient trigeminal ganglion

作者：Hu, Ze-Lan[1];Zhang, Xin[1];Shi, Ming[2];Tian, Zhi-Wen[1];Huang, Ying[3,4];Chen, Jia-Yin[3,4];Ding, Yu-Qiang[3,4]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai Comm Sci & Technol, Shanghai 200237, Peoples R China;[2]Fourth Mil Med Univ, Xijin Hosp, Dept Neurol, Xian 710032, Peoples R China;[3]East Hosp, Key Lab Arrhythmias, Minist Educ, Shanghai 200092, Peoples R China;[4]Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China

年份：2013

卷号：6

期号：7

起止页码：1261

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000324314000005)】；

基金：We thank Dr AP McMahon for providing Wnt1-Cre mice and Dr Qiufu Ma for in situ hybridization probes. This work is supported by the Shanghai Committee of Science and Technology [grant 11DZ2260600] and China Postdoctoral Science Foundation grant [No. 2012M520844] to ZeLan Hu.

语种：英文

外文关键词：Dorsal root ganglion; trigeminal ganglion; Rbpj; gliogenesis

摘要：Somatosensory ganglia including dorsal root ganglion (DRG) and trigeminal ganglion (TG) are derived from a common pool of neural crest stem cells (NCCs), and are good systems to study the mechanisms of neurogenesis and gliogenesis. Previous studies have reported that deletion of Rbpj, a critical integrator of activation signals from all Notch receptors, in NCCs and their derived cells resulted in the delayed gliogenesis at early stage and a loss of glial cells at later stage in the DRG. But the phenotypes in the TG have not been described. Here we reported although the gliogenesis was also delayed initially in Rbpj-deficient TG, it was recovered as the development progressed, as shown by the presence of large number of glial cells in the TG at later stages. However, neuronal reduction was observed in Rbpj-deficient TG, which is similar to what observed in Rbpj-deficient DRG. Taken together, our data indicate the function of Rbpj is diversified and context dependent in the gliogenesis of somatosensory ganglia.