文献类型：期刊文献

英文题名：Oxidation-Sensitive Polymersomes Based on Amphiphilic Diblock Copolypeptoids

作者：Deng, Yangwei[1,2];Chen, Hui[1];Tao, Xinfeng[1,6];Cao, Fangyi[2];Trepout, Sylvain[4,5];Ling, Jun[2];Li, Min-Hui[1,2,3]

机构：[1]PSL Univ Paris, Chim ParisTech, Inst Rech Chim Paris, CNRS,UMR8247, 11 Rue Pierre & Marie Curie, F-75005 Paris, France;[2]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, 38 Zheda Rd, Hangzhou 310027, Peoples R China;[3]Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, 15 North Third Ring Rd, Beijing 100029, Peoples R China;[4]Inst Curie, INSERM, U1196, F-91405 Orsay, France;[5]CNRS, UMR9187, F-91405 Orsay, France;[6]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2019

卷号：20

期号：9

起止页码：3435

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20193607390294);WOS:【SCI-EXPANDED(收录号:WOS:000485211000023)】；

基金：We acknowledge the French National Research Agency (project ANR-16-CE29-0028) and the National Natural Science Foundation of China (project 21528402 and 21674091) for financial support. Y.D. thanks the China Scholarship Council for funding his Ph.D. scholarship in France. We thank Yixian Wu and Patrick Keller for fruitful discussions.

语种：英文

外文关键词：Block copolymers - Photosensitizers - Biocompatibility - Hydrophilicity - Controlled drug delivery - Polyethylene glycols - Amino acids - Hydrophobicity - Targeted drug delivery - Functional polymers - Oxygen

摘要：Stimuli-responsive polymersomes formed by amphiphilic block copolymers have attracted substantial attention as smart and robust containers for drug delivery and nano/microreactors. Biosourced amphiphilic diblock copolypeptoids were developed that can self-assemble into oxidation-responsive unilamellar vesicles. These vesicles can burst under the action of reactive oxygen species which can be the hydrogen peroxide or the singlet oxygen produced by light-activation of a photosensitizer with spatiotemporal control. Polysarcosine (PSar, also called poly(N-methyl glycine)) was selected as the hydrophilic block because of its resistance to protein adsorption and low toxicity, similar to poly(ethylene glycol) (PEG). We designed and synthesized poly(N-3-(methylthio)propyl glycine) as the hydrophobic block. Its polyglycine backbone is the same as that of PSar, and especially, its hydrophobic N-substituents, thioether side chains, can be oxidized to hydrophilic sulfoxides. These oxidation-responsive polymersomes entirely based on N-substituted poly(amino acid)s were biocompatible as confirmed by cell viability tests and may find applications in drug delivery, biosensing, biodetection, and nano/microreactors.