文献类型：期刊文献

英文题名：Synthesis and biological evaluation of 3-carbamate smilagenin derivatives as potential neuroprotective agents

作者：Zhang, Cong[1];Wu, Yan[1];Li, Jie[1];Yang, Gui-Xiang[1];Su, Lin[1];Huang, Yan[1];Wang, Rui[1];Ma, Lei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：29

期号：19

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000485100200020)】；

基金：This work was supported by National Natural Science Foundation of China (81673318) and Shanghai Biomedical Technology Support Program (15401901100).

语种：英文

外文关键词：Smilagenin derivatives; Alzheimer's disease; Oxidative stress; Neuroprotective activity

摘要：Studies indicated that smilagenin, isolated from Anemarrhena asphodeloides Bunge, could improve cognitive impairment and exhibit neuroprotective activity. On the basis of the structure of smilagenin, a series of derivatives were synthesized and evaluated for their neuroprotective effects of H2O2-induced, oxygen glucose deprivation-induced neurotoxicity in SH-SY5Y cells and LPS-induced NO production in RAW264.7 cells. Structure activity relationship of derivatives revealed that benzyl-substituted piperazine formate derivatives showed the potent neuroprotective activity such as A12. These findings may provide new insights for the development of neuroprotective agents against Alzheimer's disease.