文献类型：期刊文献

英文题名：Preparation of C18-functionalized Fe3O4@SiO2 core-shell magnetic nanoparticles for extraction and determination of phthalic acid esters in Chinese herb preparations

作者：Guo, Bize[1];Ji, Shunli[1];Zhang, Feifang[1];Yang, Bingcheng[1];Gu, Jiangping[1];Liang, Xinmiao[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：100

起止页码：365

外文期刊名：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343021100047)】；

基金：The work has been financially supported by National Natural Science Foundation of China (nos. 21477037, 21322502).

语种：英文

外文关键词：Functionalized magnetic nanoparticles; Core-shell; Extraction; Phthalic acid esters; High performance liquid chromatography

摘要：The extraction and determination of phthalic acid esters (PAEs) residue in Chinese herbal preparations (CHP) by C-18-functionalized magnetic nanoparticles (C-18-FS-MNP) has been firstly performed. It was synthesized through coating Fe3O4 nanoparticles with sodium silicate, followed by freeze-drying technique and then modified with C-18 groups. C-18-FS-MNPs prepared via freeze-drying technique were superior to those particles prepared via common vacuum drying method in terms of dispersion and extraction recovery. C-18-FS-MNPs demonstrated obvious enrichment effect for four model PAEs and 478-627-fold enrichment factors were obtained. The limit of detection was <1.89 ng/mL and relative standard deviation was ranging from 3.7 to 5.8%. It was successfully applied for determination of trace PAEs residue in CHP with good recoveries. (C) 2014 Elsevier B.V. All rights reserved.