文献类型：期刊文献

英文题名：Controlling solid form and crystal habit of triphenylmethanol by antisolvent crystallization in a microfluidic device

作者：Lu, Jun[1];Yan, Jinrui[1];Guo, Yaohao[1];Qiu, Junjie[1];Zhao, Shuangliang[1,2,3];Bao, Bo[1]

机构：[1]East China Univ Sci & Technol, Shanghai 200237, Peoples R China;[2]Guangxi Univ, Guangxi Key Lab Petrochem Resource Proc & Proc Int, Nanning 530004, Peoples R China;[3]Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Peoples R China

年份：2024

卷号：35

期号：4

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001170309800001)】；

基金：This work is supported by the National Natural Science Founda- tion of China (No. 22278128) .

语种：英文

外文关键词：Microfluidics; Triphenylmethanol; Antisolvent crystallization; Crystal habit; Solid form

摘要：Crystal habit and crystal form are critical elements in determining product properties and functions. In this work, we developed a microfluidic antisolvent crystallization technique to rapidly screen and accurately control the solid form and crystal habit of triphenylmethanol (Ph3COH). This advanced technique separates the primary mixing of solutions from crystal formation (nucleation and growth) by introducing the microfluidic device, avoiding clogging in microchannels to obtain high-quality crystals. The results show that we can achieve controllable preparation of pure 2Ph(3)COHDMSO (DMSO solvate), pure Ph3COH (form beta), and mixed crystals with different mass ratios. Moreover, the microscale can prompt the DMSO solvate to grow into hexagonal sheet-like and bulk crystals. We can regulate the aspect ratio of hexagonal sheet-like crystals in binary solvents and control the crystal habit of the form beta to transition between long needle-like shapes and short hexagonal prisms in DMF-H2O. Meanwhile, we revealed that the solvent ratio, the antisolvent flow rate, and the initial concentration of Ph3COH are the main factors affecting the solid form selectivity and morphology transition. Such a novel method would be considered as a promising technique to be extended to screen and control key crystallization parameters of other substances. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.