文献类型：期刊文献

英文题名：Room-temperature nickel-catalyzed borylation/cyclization for the synthesis of benzoxaboroles and benzodiazaborines

作者：Yang, Xiaoning[1];Wu, Shuyan[1];Wang, Jiayi[1];Peng, Yanqing[1];Song, Gonghua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2025

卷号：12

期号：20

起止页码：5547

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20252618671511);WOS:【SCI-EXPANDED(收录号:WOS:001513017600001)，CCR-EXPANDED(收录号:WOS:001513017600001)】；

语种：英文

外文关键词：Bioactivity - Catalysis - Catalysts - Cost effectiveness - Drug discovery - Drug products - Medicinal chemistry - Sustainable chemistry

摘要：Benzoxaboroles and benzodiazaborines are pivotal in medicinal chemistry due to their unique biological activities and potential as therapeutic agents. Herein, we present a room-temperature, nickel-catalyzed borylation protocol for their efficient synthesis. Utilizing an inexpensive nickel catalyst system, this method provides a facile synthetic method for a wide range of target compounds. This cost-effective approach offers a sustainable alternative to traditional palladium-based methods, aligning with green chemistry principles by reducing energy input and enhancing reaction efficiency. In addition to expanding the range of boronic acid derivatives, the developed methodology holds significant promise for advancing applications in drug discovery.