文献类型：期刊文献

英文题名：Supersaturation and solubilization of poorly water-soluble phloretin in tween surfactant solutions

作者：Jing, Yifei[1]; Ning, Deyong[1]; Wang, Kangqi[1]; Yang, Shixin[1]; Jianxin[1]; Guo[1]; Wang, Xiaoyong[1]

机构：[1] School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2026

卷号：444

外文期刊名：Journal of Molecular Liquids

收录：EI(收录号：20260119846479)

语种：英文

外文关键词：Carbon - Chemical shift - Hydrogen - Hydrophobic chromatography - Hydrophobicity - Micelles - Surface active agents - Surface chemistry

摘要：The supersaturation and solubilization of poorly water-soluble phloretin (PHL) are investigated in the solutions of Tween-40, Tween-60, and Tween-80 carrying the same headgroup except different alkyl chain structure. PHL gives markedly different dissolution curves with 0.01, 0.1, and 1 mM Tween-40, corresponding to Tween-40 monomers, small micelles, and large micelles, respectively. While Tween-40 monomers can slightly increase the solubility of PHL, it is seen that PHL has the "spring and parachute" and solubilizating phenomena in Tween-40 small micelles and large micelles, respectively. The supersaturation degree of PHL in 0.1 mM Tween surfactant solutions has the order of Tween-80 small micelles > Tween-60 small micelles > Tween-40 small micelles. The equilibrium solubilities of PHL with Tween-40 large micelles, Tween-60 vesicles, and Tween-80 large micelles are 23.6, 21.1, and 24.8 times that of PHL in water, respectively. 1H NMR data reveal that both hydrogen bonding and hydrophobic interaction are involved in the supersaturation and solubilization behaviors of PHL, which are closely related to the alkyl chain structure and aggregation level of Tween surfactants. Compared to Tween-40 and Tween-60, Tween-80 having an alkyl chain with a carbon?carbon double bond has stronger hydrophobic interaction with PHL, leading PHL to have higher supersaturation degree and solubilization in Tween-80 small micelles and large micelles. Nevertheless, the compact bilayer of Tween-60 vesicles is more difficult for PHL to bind than the palisade layer of Tween-40 and Tween-80 large micelles, which is indicated by the smallest chemical shift changes of Tween-60 as well as the values of PHL anisotropy. ? 2025 Elsevier B.V.