文献类型：期刊文献

英文题名：Stimuli-responsive hydrogels: Fabrication and biomedical applications

作者：Li, Ziyuan[1];Zhou, Yanzi[1];Li, Tianyue[1];Zhang, Junji[1];Tian, He[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：3

期号：2

外文期刊名：VIEW

收录：EI(收录号：20221311845363);WOS:【ESCI(收录号:WOS:000691327900001)】；

基金：NSFC, Grant/Award Numbers: 21878086, 21788102, 22020102006; ShanghaiRisingStar Program, Grant/Award Number: 19QA1402500; ShanghaiMunicipal Science andTechnologyMajor Project, Grant/Award Number: 2018SHZDZX03; Shanghai Science andTechnology Committee, Grant/Award Number: 17520750100; FundamentalResearch Funds for the CentralUniversities, Grant/AwardNumber: 222201717003; Shanghai Sailing Program, Grant/Award Number: 20YF1410300; China Postdoctoral Science Foundation, Grant/Award Number: 2020M671017

语种：英文

外文关键词：bio-application; cell regulation; drug delivery; hydrogel; wound dressing

摘要：Due to their similarity to some bio-architectures, for example, extracellular matrix, hydrogels are considered as bio-inspired networks with bio-mimetic and bio-functional properties. With natural cytocompatibility and biocompatibility, hydrogels nowadays are more and more involved in various bio-applications including shape morphing, artificial muscles, soft robotics, regenerative medicine, and so on. As an important subclass, stimuli-responsive hydrogels have been attracting interest within decades. In response to single or multi-triggers in biological microenvironment, stimuli-responsive hydrogels can undergo phase transition, stiffness change, or biochemical properties activation, which make them intriguing biomaterials with broad applications including sensing, drug delivery, tissue engineering, and wound healing. This review presents typical synthetic and natural gelators comprising small molecules and polymers as building blocks of functional architectures. The fabrication strategies of hydrogels varied from supramolecular assembly to dynamic covalent binding are detailed. Various exogenous or endogenous, physical or chemical, and synthetic or natural stimuli together with response mechanism, design principle are demonstrated. Through recent examples from different perspectives, such as bionic devices, wound dressing, and cargo carrier, the benefits and opportunities of stimuli-responsive hydrogels for biological applications are highlighted. Finally, the current challenges and future prospects in view of translation from fundamental researches to clinical application are briefly discussed.