文献类型：期刊文献

英文题名：Engineering photo-controllable fragrance release with flash nanoprecipitation

作者：Liu, Ming[1,2];Yan, Chenxu[1,2];Han, Jianwei[1,2];Guo, Zhiqian[1,2];Wu, Yue[3];Huang, Jian[3];Xiao, Zuobing[4];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat,Shanghai Key L, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Inst Fine Chem,Joint Int Res L, Shanghai 200237, Peoples R China;[3]Apple Flavor & Fragrance Grp Co Ltd, Shanghai 200436, Peoples R China;[4]Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China

年份：2021

卷号：2

期号：3

起止页码：301

外文期刊名：GREEN CHEMICAL ENGINEERING

收录：EI(收录号：20224313013011);WOS:【ESCI(收录号:WOS:001075071800001)】；

基金：The authors are grateful for the financial support provided by National Key Research and Development Program (2016YFA0200300), NSFC Science Center Program (21788102) and Creative Research Groups (21421004), NSFC/China (21636002 and 21622602), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), and Program of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：Photo-triggered profragrances; Flash nanoprecipitation; Tunable nanoparticles; Controllable fragrance release

摘要：Controllable profragrance nanoparticles are in great demand for long-lasting scent in flavor and fragrance industries. However, the practical applications of controllable fragrance release are limited by the non-tunable size, structural heterogeneity and poor reproducibility. Herein, a coumarin-derived phototrigger (CM-OH) is covalently conjugated with alcohol fragrances to obtain the corresponding profragrances (CM-R) which enable to release fragrances under the light controlling conditions. Furthermore, we introduce a new engineering strategy to construct fine tunable and highly uniform profragrance nanoparticles with flash nanoprecipitation (FNP) technology, which features commercial available amphiphilic pluronic F127 polymers by encapsulation of photoactivatable profragrances CM-R in hydrophobic cores to enhance the long-lasting photo-controllable fragrance release. With the assistance of FNP technology, amphiphilic pluronic polymer and profragrances CM-R in organic solution are instantaneously mixed and subsequently precipitated in the multi-inlet vortex mixer (MIVM), thus obtaining the pluronic F127-encapsulated profragrance nanoparticles with good homogeneity. Compared to the traditional thermodynamic encapsulation method, the novel kinetic FNP technology can not only tune the size of profragrance nanoparticles with narrow distribution, but also distinctly improve the batch-to-batch reproducibility, which affords an alternative method for scale-up preparation of amphiphilic profragrance nanoparticles in precisely controllable fragrance delivery system.