文献类型：期刊文献

英文题名：DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test

作者：Li, Kui[1,2];Liu, Ji-Wei[1];Zhu, Zhi-Chuan[1];Wang, Hong-Tao[1];Zu, Yong[1];Liu, Yong-Jie[1];Yang, Yan-Hong[1];Xiong, Zhi-Qi[1];Shen, Xu[2];Chen, Rui[3];Zheng, Jing[1];Hu, Ze-Lan[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;[3]Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

年份：2014

卷号：7

期号：10

起止页码：6486

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000345135900007)】；

语种：英文

外文关键词：DSTYK; knockout mice; brain development; learning and memory

摘要：DSTYK (Dual serine/threonine and tyrosine protein kinase) is a putative dual Ser/Thr and Tyr protein kinase with unique structural features. It is proposed that DSTYK may play important roles in brain because of its high expression in most brain areas. In the present study, a DSTYK knockout (KO) mouse line with the ablation of C-terminal of DSTYK including the kinase domain was generated to study the physiological function of DSTYK. The DSTYK KO mice are fertile and have no significant morphological defects revealed by Nissl staining compared with wildtype mice. Open field test and rotarod test showed there is no obvious difference in basic motor and balance capacity between the DSTYK homozygous KO mice and DSTYK heterozygous KO mice. In water maze test, however, the DSTYK homozygous KO mice show impaired capabilities of learning and memory compared with the DSTYK heterozygous KO mice.