文献类型：期刊文献

英文题名：Electronic Inputs to Cue the Emergence of Hydrogel Structure and to Confer Function

作者：Liu, Yi[1]; Lei, Miao[2]; Li, Jinyang[1]; Kim, Eunkyoung[1]; Yan, Kun[3]; Bentley, William E.[1,4]; Shi, Xiaowen[5]; Qu, Xue[2]; Payne, Gregory F.[1]

机构：[1] Institute for Bioscience and Biotechnology Research, Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD, 20742, United States; [2] Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, East China University of Science and Technology, Shanghai, 200237, China; [3] Hubei Key Laboratory of Advanced Textile Materials & Application, Wuhan Textile University, Wuhan, 430200, China; [4] Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, United States; [5] School of Resource and Environmental Science, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Engineering Center of Natural Polymers-Based Medical Materials, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230208086)

语种：英文

外文关键词：Chitosan - Covalent bonds - Electric fields - Electrodeposition - Electrodes - Hierarchical systems - Sulfur compounds

摘要：Electrode-imposed electronic inputs can generate various cues that can control the emergence of hierarchical structure and confer function to hydrogel systems. Here we describe three such top-down cues. Electrolytic reactions can create pH cues that can induce the electrodeposition of pH-responsive self-assembling polymers (e.g., chitosan and alginate). The electric field provides a long-range cue that can induce polymer chains to migrate toward (or away from) the electrode and can align the polymer chains within the assembling hydrogel network (e.g., collagen). The electrochemical generation of diffusible oxidants provides a molecular cue that can induce oxidative assembly - typically through the formation of covalent bonds (e.g., disulfide bonds). Here, we review recent results on the use of these three cues for the electrofabrication of hydrogels and we illustrate how complementary capabilities from biotechnology allow the creation of functional hydrogel systems. Overall, we envision that electro-bio-fabrication could emerge as a scalable additive manufacturing method as well as a flexible approach for distributed manufacturing in public maker spaces. ? 2023, The Authors. All rights reserved.