文献类型：期刊文献

英文题名：Novel Bionic Topography with MiR-21 Coating for Improving BoneImplant Integration through Regulating Cell Adhesion and Angiogenesis

作者：Geng, Zhen[1];Li, Zhaoyang[2];Cui, Zhenduo[2];Wang, Jing[3,4];Yang, Xianjin[2];Liu, Changsheng[5,6]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Tianjin Univ, Tianjin Key Lab Composite & Funct Mat, Sch Mat Sci & Engn, Tianjin 300350, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[6]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：20

期号：10

起止页码：7716

外文期刊名：NANO LETTERS

收录：;EI(收录号：20204609477593);WOS:【SCI-EXPANDED(收录号:WOS:000613073900026)】；

基金：This work was financially supported by National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002), China Postdoctoral Science Foundation (Grant No. 2018M640350), National Natural Science Foundation of China (Grant No. 51871163), and Shanghai International S&T Cooperation Project (Grant No. 18520710100).

语种：英文

外文关键词：Bionic topography; integrin; cell adhesion; angiogenesis; osseointegration

摘要：Implant loosening is still the major form of the failure of artificial joints. Herein, inspired by the operculum of the river snail, we prepared a novel bionic micro/nanoscale topography on a titanium surface. This bionic topography promoted early cell adhesion through up-regulating the expression of ITG alpha 5 beta 1 and thus accelerated the following cell spreading, proliferation, and differentiation. Moreover, a miR-21 coating, which promoted the angiogenic differentiation of MSCs, was fabricated on the bionic topography. Benefiting from both bionic micro/nanoscale topography and miR-21, blood vessel growth and bone formation and mineralization around the implant, as well as bone-implant bonding strength, were significantly improved. Collectively, the present study highlights the combination of the bionic micro/nanoscale topography and miR-21 on promoting cell adhesion and angiogenic differentiation and improving in vivo angiogenesis and bone-implant osseointegration. This work provides a new train of thought propelling the development of implants for potential application in the orthopedics field.