文献类型：期刊文献

英文题名：Synthesis of 2-Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature

作者：Fan, Huaqiang[1,2];Pang, Peng[1,2];Zhang, Yongqiang[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

年份：2018

卷号：20

期号：24

起止页码：7929

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000454567800041)，CCR-EXPANDED(收录号:WOS:000454567800041)】；

基金：Financial support from the program of the National Natural Science Foundation of China (21602060, 21871086, Y.-QZ.; 21572055, 21738002, W.W.) and the Chinese Fundamental Research Funds for the Central Universities (ECUST: WY1714033) is gratefully acknowledged.

语种：英文

摘要：A hypervalent iodine(III)-mediated intramolecular decarboxylative Heck-type reaction of 2-vinyl-phenyl oxamic acids has been developed. The unique ring-strain-enabled radical decarboxylation mechanism is preliminarily revealed. This protocol features metal-free reaction conditions and operational simplicity, allowing the lactamization of 2-vinylanilines using a readily accessible carbonyl source and the synthesis of various 2-quinolinones with excellent chemoselectivity at room temperature.