文献类型：期刊文献

英文题名：Enantioselective Desymmetrization of Bicyclic Hydrazines using a C2-Symmetric N-Heterocyclic Carbene (NHC) Palladium Complex as Catalyst

作者：Gu, Peng[1,2];Xu, Qin[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：32

期号：24

起止页码：7575

外文期刊名：ORGANOMETALLICS

收录：;EI(收录号：20141317509898);WOS:【SCI-EXPANDED(收录号:WOS:000329137900040)，CCR-EXPANDED(收录号:WOS:000329137900040)】；

基金：We thank the Shanghai Municipal Committee of Science and Technology (11JC1402600), the National Basic Research Program of China ((973)-2010CB833302), the Fundamental Research Funds for the Central Universities, and the National Natural Science Foundation of China for financial support (21072206, 20472096, 21372241, 20672127, 21102166, 21121062, 21302203, 21361140350, and 20732008).

语种：英文

外文关键词：Organic compounds - Enantioselectivity - Hydrazine - Palladium compounds

摘要：The first example of palladium-catalyzed enantioselective desymmetrization of 2,3-bicyclic hydrazines with arylboronic acids through a ring-opening process is described by using a chiral C-2-symmetric N-heterocyclic carbene (NHC) palladium complex as the catalyst. The reaction can be performed under convenient conditions to give trans-1,2-disubstituted 3-cyclopentenes 3 with high regioselectivity in good to excellent yields (up to 95%) and moderate to good enantioselectivities (up to 88% ee).