文献类型：期刊文献

英文题名：1,8-naphthalimide hydroperoxides as novel intercalating DNA cleavers

作者：Tao, Zhi-Fu[1]; Qian, Xuhong[1]; Wei, Dongzhi[1]

机构：[1]E CHINA UNIV SCI & TECHNOL,INST PESTICIDES & PHARMACEUT,SHANGHAI 200237,PEOPLES R CHINA;[2]E CHINA UNIV SCI & TECHNOL,INST BIOTECHNOL,SHANGHAI 200237,PEOPLES R CHINA

年份：1996

卷号：31

期号：3

起止页码：245

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：1996403282494);WOS:【SCI-EXPANDED(收录号:WOS:A1996UY16600007)】；

语种：英文

外文关键词：DNA - Intercalation compounds - Synthesis (chemical) - Thermal effects

摘要：Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated, They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA, Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition. Copyright (C) 1996 Elsevier Science Ltd