文献类型：期刊文献

英文题名：Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins

作者：Meng, Jiang;Jia, Renmeng;Leng, Jiaying;Wen, Min;Yu, Xingxin[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：19

期号：17

起止页码：4520

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000409566400028)，CCR-EXPANDED(收录号:WOS:000409566400028)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21402049)

语种：英文

摘要：A novel protocol for the synthesis of unsymmetrical indigo-like (E)-alpha-amino enaminones by rhodium catalyzed transformations of isatins with 1-tosy1-1,2,3-triazoles has been developed. A plausible reaction mechanism is proposed to account for the formation of structurally important unsymmetrical indigo analogues, which represents a new strategy for C-C bond formation based on the transformations of secondary amides and rhodium azavinylcarbenes.