文献类型：期刊文献

英文题名：Cationic-anionic synchronous ring-opening polymerization

作者：Wang, Wenli[1,2];Liang, Xue[2];Liu, Hengxu[2];Zhang, Jiamin[2];Zhang, Yuanzu[2];Zhang, Beibei[2];Li, Jianhua[2];Zhu, Yunqing[2];Du, Jianzhong[1,2,3]

机构：[1]Tongji Univ, Shanghai Peoples Hosp 4, Sch Med,Dept Gynecol & Obstet,Translat Res Inst Br, Clin Res Ctr Anesthesiol & Perioperat Med,Shanghai, Shanghai 200434, Peoples R China;[2]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：16

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001428639500004)】；

基金：W.W. would like to acknowledge support from National Natural Science Foundation of China (22401216). Y.Z. acknowledges support by National Natural Science Foundation of China (22175131), the Interdisciplinary Collaborative Research Project of Tongji University (2023-2-YB-03) and Tongcheng Youth Research and Development Fund (CPCIF-RA-0104). J.D. acknowledges support by National Natural Science Foundation of China (21925505 and 22335005), National Key R&D Program of China (2022YFC2402900) and Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28). J.D. is the recipient of National Science Fund for Distinguished Young Scholars. The authors acknowledge Dr. Erik J. Cornel for useful discussion.

语种：英文

摘要：Chemical reactions with incompatible mechanisms (such as nucleophilic reactions and electrophilic reactions, cationic polymerization and anionic polymerization) are usually difficult to perform simultaneously in one-pot. In particular, synchronous cationic-anionic polymerization has been an important challenge in the field of polymer synthesis due to possible coupling termination of both chain ends. We recently found that such terminal couplings can be significantly inhibited by a bismuth salt with a strong nucleophilic anion (e.g., BiCl3) and disclosed the mechanism. Accordingly, we propose a cationic-anionic polymerization (CAP) method where cationic ring-opening polymerization (CROP) of 2-oxazolines (Ox) and anionic ring-opening polymerization (AROP) of cyclic esters (CE) can be initiated sequentially and propagated simultaneously in one-pot, using bismuth salts as the initial initiators, to afford a multifunctional copolymer polyoxazoline-block-polyester (POx-b-PCE). Furthermore, a block copolymer PAPOZ20-b-PCL5 synthesized by CAP can self-assemble into micellar aggregates, which exhibit excellent intrinsic antibacterial activities without loading any extra antibiotic components. Overall, such a CAP method opens new avenues for synthesizing multi-component copolymers and biomaterials.