文献类型：期刊文献

英文题名：One-step preparation of glycopeptide microspheres based on α-amino acid-n-carboxyanhydride polymerization using interfacial protocols

作者：Wang, Jing[1]; Liu, Changsheng[1]; Chi, Ping[1]

机构：[1] Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China

年份：2009

卷号：89

期号：1

起止页码：45

外文期刊名：Journal of Biomedical Materials Research - Part B Applied Biomaterials

收录：EI(收录号：20092112087776)

语种：英文

外文关键词：Emulsions - Grafting (chemical) - Amino acids - Copolymerization - Emulsification - Hybrid materials - Biomimetics - Drug delivery

摘要：A type of polysaceharide-polypeptide hybrid material, chitln derivative with polypeptide side chains was prepared by the graft copolymerization of L-leucine N-earboxyanhydride triggered by water-soluble chitin (WSC). The studies on surface tension and aggregation demonstrated surface activity of WSC, Using this extraordinary property, the microspheres were synchronously obtained via interfacial polymerization. The method employed here to form the microspheres was in direct contrast to previous syntheses that used either templating method or oil-in-water emulsion. The study provided a facile approach for synthesizing microspheres with a variety of distinct polypeptide and regulated graft length, which had mimetic structure of glycoconjugation in extracellular matrix. Furthermore, the swelling capability of the microsphere in both acidic aqueous and organic solvents would give promising application in drug delivery, ? 2008 Wiley Periodicals, Inc.