文献类型：期刊文献

英文题名：Asymmetric Direct Michael Addition of Acetophenone to α,β-Unsaturated Aldehydes

作者：Li, Wenjun[1];Wu, Wenbin[1];Yang, Juanjuan[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

期号：7

起止页码：1085

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20111313874166);WOS:【SCI-EXPANDED(收录号:WOS:000288848900010)，CCR-EXPANDED(收录号:WOS:000288848900010)】；

基金：We thank the National Natural Science Foundation of China (20902018), Shanghai Pujiang Program (08PJ1403300), Innovation Program of Shanghai Municipal Education Commission (11ZZ56), and the Fundamental Research Funds for the Central Universities for financial support of this work.

语种：英文

外文关键词：asymmetric catalysis; Michael additions; ketones; aldehydes; enals

摘要：The asymmetric direct Michael addition of alpha,beta-unsaturated aldehydes with acetophenone catalyzed by a Jorgensen-Hayashi catalyst in methanol was developed and the corresponding Michael products of delta-keto aldehydes could be afforded in up to 82% yield and 98% ee.