文献类型：期刊文献

英文题名：Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides

作者：Huang, Wenyi[1];Wang, Yun[1];Weng, Yangyang[1];Shrestha, Mohini[1];Qu, Jingping[1];Chen, Yifeng[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Shanghai 200237, Peoples R China

年份：2020

卷号：22

期号：8

起止页码：3245

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000526894000076)，CCR-EXPANDED(收录号:WOS:000526894000076)】；

基金：This work was supported by the Youth 1000-Talent Plan Program, East China University of Science and Technology, NSFC/China (21421004, 21702060), Shanghai Municipal Science and Technology Major Project (Grant No.2018SHZDZX03) and the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities (WJ1814012). The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on NMR analysis.

语种：英文

摘要：Herein, we disclose a Ni-catalyzed formal amin-ocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, which proceeds via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent beta-hydride elimination, and hydrolysis process. The reaction features wide functional group tolerance under mild conditions. Additionally, the selective, one-pot hydrolysis of reaction mixture under acid conditions allows for expedient synthesis of the corresponding alkyl carboxylic acid.