文献类型：期刊文献

英文题名：Phenylboronic acid conjugated mPEG-b-PCL micelles as DOX carriers for enhanced drug encapsulation and controlled drug release

作者：Yin, Wang[1];Wang, Yixiu[2,3];Xiao, Yan[1];Mao, Anrong[2,3];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Fudan Univ, Dept Hepat Surg, Shanghai Canc Ctr, Shanghai, Peoples R China;[3]Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

年份：2022

卷号：173

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20222012123865);WOS:【SCI-EXPANDED(收录号:WOS:000804599900003)】；

基金：Acknowledgements This research was supported by the National Key Research and Development Program (2016YFC1100703) .

语种：英文

外文关键词：Polymeric micelles; Poly(?-caprolactone); Drug loading; Controlled release; Anti-tumor

摘要：Polymeric micelles represent an important delivery platform for hydrophobic drugs, but limited by unsatisfactory drug loading, micellar stability and controlled release. Herein, poly(epsilon-caprolactone) block copolymers with three different pendant groups (tert-butyl formate, carboxylate, and phenylboronic acid formate) were prepared by organocatalytic ring-opening polymerization and post modification. All three block polymers with different pendant groups can form micelles by self-assembly with uniform size of approximately 100 nm and narrow distribution. In particular, the DOX-loaded micelles with phenylboronic acid (PBA) conjugation exhibit high encapsulation efficiency (greater than95 %) and colloidal stability of constant basic particle size over a week. Besides, compared to the other two groups of drug-loaded micelles, the PBA-modified drug-loaded micelles can selectively release drugs by triggering with H2O2. After treatment with 100 mu M H2O2, the cumulative drug release from micelles increased by 2.5 times in PBS solution at pH 7.4. More importantly, drug-loaded micelles of PBA modifying can be selectively released according to the high level of reactive oxygen species in cancer cells, which could improve anti-cancer efficacy and reduce toxic side effects. The micelle covalently modified by PBA was demonstrated as a promising drug carrier for DOX delivery.