文献类型：期刊文献

英文题名：Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy

作者：Liu, Qiang[1];Sun, Chuyang[1];Dai, Ruilong[1];Yan, Chenxu[1];Zhang, Yutao[1];Zhu, Wei -Hong[1];Guo, Zhiqian[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem,Inst Fine Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China

年份：2024

卷号：503

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001153804200001)】；

基金：This work was supported by NSFC/China (22225805, 21878087, 22378122, 32394001, and 32121005) , National Key Research and Development Program (2021YFA0910000) , Shanghai Science and Technology Innovation Action Plan (No. 23J21901600) , Innovation Program of Shanghai Municipal Education Commission, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28) , Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03) , Shanghai Science and Technology Committee Rising -Star Program (22QC1400400) and Programme of Introducing Talents of Discipline to Universities (B16017) , Natural Science Foundation of Shanghai (23ZR1416600) .

语种：英文

外文关键词：Dicyanomethylene-4H-pyran; Near-infrared; Fluorescent probe; Photodynamic therapy; Photothermal therapy

摘要：Near-infrared (NIR) fluorescence imaging, with its deep tissue penetration, reduced autofluorescence, and improved signal-to-noise ratios, offers immense potential for in vivo applications including biomolecule sensing, cancer research, and drug delivery. The development of high-stable and bright NIR fluorophores is in high demand for precise biosensing and imaging. Dicyanomethylene-4H-pyran (DCM) derivatives, firstly introduced in 1989 as a highly fluorescent dopant for the development of red organic light-emitting diodes, have emerged as versatile fluorophores with excellent properties, including high sensitivity, long emission wavelength to the NIR region, and high fluorescent yield. In this review, we focus on recent advances in engineering DCM-based fluorophores for NIR biosensing and phototherapy. Specifically, we discuss the DCM dyes' structure-property relationship for extending the emission wavelength and enhancing emission intensity in molecular or aggregate state, and strategies for modulating the excited states of DCM chromophores to develop activatable (including off-on activation, ratiometric sensing, and high-fidelity labeling) fluorescent/chemiluminescent probes. We also discuss how to regulate intersystem crossing and excited-state intramolecular motion of DCM chromophores to enhance the efficiency of phototherapy. It is hoped that this review provides deepening of research on DCM chromophores for the development of novel high-performance NIR probes for physiological/pharmacological studies and clinical applications.