文献类型：期刊文献

英文题名：Biosynthetic origin of the carbon skeleton of a novel anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp.

作者：Niu, Chuanpeng[1]; Cai, Menghao[1]; Zhang, Yuanxing[1]; Zhou, Xiangshan[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237 Shanghai, China

年份：2012

卷号：34

期号：11

起止页码：2119

外文期刊名：Biotechnology Letters

收录：EI(收录号：20124115548551)

语种：英文

外文关键词：Drug products - Ketones - Biosynthesis - Alkylation - Carbon - Musculoskeletal system

摘要：Purpose of work:: The biosynthetic pathway of a new antitumor compound, haloroquinone, is elucidated to facilitate metabolic regulation for product accumulation and modification to produce new bioactive structural analogues of the compound. The biosynthetic origin of a novel promising protein kinase B inhibitor and anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp. was clarified. The origin of carbon skeleton of haloroquinone was elucidated by feeding experiments with [2-13C]malonate and [1,2,3-13C3]malonate followed by 13C-NMR analysis of the isolated compounds: 15 carbon atoms were derived from malonate, of which eight were from the methylene group and seven from the carboxyl group. The remaining one is probably obtained by O-methylation. Haloroquinone is thus synthesized via a polyketide pathway using malonyl-CoA as both the starter unit and the extender unit. ? 2012 Springer Science+Business Media B.V.