文献类型：期刊文献

英文题名：Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix

作者：Su, Teng[1,2,3];Liu, Yi[4];He, Hongjian[1];Li, Jia[4];Lv, Yanan[1];Zhang, Lili[4];Sun, Yao[4];Hu, Chunpu[5]

机构：[1]Tongji Univ, Adv Res Inst, Dept Chem, Shanghai 200092, Peoples R China;[2]Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27514 USA;[3]North Carolina State Univ, Raleigh, NC 27695 USA;[4]Tongji Univ, Lab Oral Biomed Sci & Translat Med, Sch Stomatol, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Shanghai 200072, Peoples R China;[5]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2016

卷号：5

期号：11

起止页码：1217

外文期刊名：ACS MACRO LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000388161100006)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 81571017 and 81470715), the Fundamental Research Funds for Central Universities, and the Recruitment Program of Global Experts.

语种：英文

摘要：Inspired by the delicate architecture of hyaline articular cartilage, we report on a biomimetic polymer hydrogel that incorporates strong intermolecular hydrogen bonding between urethane-urethane linkages as well as urethane-ester linkages. The resultant hydrogel, containing approximate to 75% water, can endure a compressive stress up to 56 MPa with a strain of 98%, and exhibit tunable compressive modulus (0.19-1.38 MPa), as well as toughness (3629-28290 J m(-2)) within a wide range. The tensile strength and elastic modulus reach as high as 0.56 and 5.5 MPa, respectively. The high stiffness and toughness enable the gel to withstand cyclic compressive loadings without fracturing. Moreover, our hydrogel mimics the extracellular matrices of cartilage and bone tissues and provides biochemical and physical cues that support the three-dimensional proliferation of chondrocytes and osteogenic differentiation of preosteoblasts.