文献类型：期刊文献

英文题名：A Drug-Free Therapeutic System for Cancer Therapy by Diselenide-Based Polymers Themselves

作者：Wei, Chao[1];Liang, Bingyu[2];Li, Yongsheng[3,4];Yan, Bingkun[1];Zhou, Yan[2];Liu, Yingbin[3,4];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat & Sci & Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Dept Gen Surg, Xinhua Hosp, Shanghai 200092, Peoples R China;[4]Shanghai Res Ctr Biliary Tract Dis, Shanghai Key Lab Biliary Tract Dis, Shanghai 200092, Peoples R China

年份：2021

卷号：10

期号：2

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20204309403761);WOS:【SCI-EXPANDED(收录号:WOS:000583791000001)】；

基金：C.W., B.Y.L., and Y.S.L. contributed equally to this work. The authors thank the National Key Research and Development Program (Grant Nos. 2016YFC1100703 and 2018YFC1105800) and Fundamental Research Funds for the Central Universities (Grant No. 22221818014). Animal studies were approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine in accordance with guidelines for the care and use of animals.

语种：英文

外文关键词：cancer therapy; drug‐ free therapeutic systems; poly(diselenide‐ carbonate); reactive oxygen species; self‐ anticancer activity

摘要：The application of nanotechnology-based drug delivery systems has resulted in great progresses in cancer therapy. However, current systems ultimately depend on the action of the drug itself and almost all nanocarriers only serve as excipients without any therapeutic efficacy. Herein, a drug-free therapeutic system is put forward, in which synthetic polymers themselves naturally exhibit effective anticancer activity without the loading of additional chemotherapy drugs. Aiming at this goal, amphiphilic poly(diselenide-carbonate) copolymers (PSeSeTMC), consisting of monomethyl ether poly(ethylene glycol) and diselenide-based polycarbonates, are designed and synthesized to build spherical nanoparticles, which show effective and broad-spectrum anticancer activities against multiple cancer cell lines and high selectivity toward cancer cells. Moreover, the anticancer activities can be well controlled by tuning the selenium contents in polymers. Mechanistic investigations indicate that PSeSeTMC can selectively induce cancer cells to express excessive reactive oxygen species, thereby leading to significant cellular apoptosis. In vivo antitumor studies further demonstrate high therapeutic efficacy and low side effects on normal tissue. Overall, this work provides a novel approach for cancer therapy by utilizing carriers themselves. Considering the fabrication process is pretty simple, this diselenide-based polymeric system has great potential in clinical translation.