文献类型：期刊文献

英文题名：Antioxidant and Immunomodulatory Polymer Vesicles for Effective Diabetic Wound Treatment through ROS Scavenging and Immune Modulating

作者：Zhang, Wenqing[1];Ge, Zhenghong[1];Xiao, Yufen[2];Liu, Danqing[3];Du, Jianzhong[1,2,3,4]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[2]Tongji Univ, Shanghai Peoples Hosp 4, Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Clin Res Ctr Anesthesiol & Perioperat Med,Translat, Shanghai 200434, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：24

期号：31

起止页码：9494

外文期刊名：NANO LETTERS

收录：;EI(收录号：20243116775149);WOS:【SCI-EXPANDED(收录号:WOS:001279686900001)】；

基金：This research was supported by National Key R&D Program of China (2022YFC2402900), National Natural Science Foundation of China (22335005, 21925505, 22305176), Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), the international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality (21520710100), and the China Postdoctoral Science Foundation (2024T170667 and 2023M732630). J.D. is the recipient of a 5-year National Science Fund for Distinguished Young Scholars.

语种：英文

外文关键词：diabetic wounds; vesicles; Treg cells; antioxidant; immune regulation; self-assembly

摘要：Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in high reactive oxygen species (ROS) levels and immune cell dysfunction, prolonged inflammation, and delayed wound healing. Herein, we prepared an antioxidant and immunomodulatory polymer vesicle for diabetic wound treatment. This vesicle is self-assembled from poly(epsilon-caprolactone)(36)-block-poly[lysine(4)-stat-(lysine-mannose)(22)-stat-tyrosine)(16)] ([PCL36-b-P[Lys(4)-stat-(Lys-Man)(22)-stat-Tyr(16)]). Polytyrosine is an antioxidant polypeptide that can scavenge ROS. d-Mannose was introduced to afford immunomodulatory functions by promoting macrophage transformation and Treg cell activation through inhibitory cytokines. The mice treated with polymer vesicles showed 23.7% higher Treg cell levels and a 91.3% higher M2/M1 ratio than those treated with PBS. Animal tests confirmed this vesicle accelerated healing and achieved complete healing of S. aureus-infected diabetic wounds within 8 days. Overall, this is the first antioxidant and immunomodulatory vesicle for diabetic wound healing by scavenging ROS and regulating immune homeostasis, opening new avenues for effective diabetic wound healing.