文献类型：期刊文献

英文题名：Water-soluble dendritic-linear triblock copolymer-modified magnetic nanoparticles: preparation, characterization and drug release properties

作者：Wu, Xiaomeng[1];He, Xiaohua[1,2];Zhong, Liang[1];Lin, Shaoliang[2];Wang, Dali[3];Zhu, Xinyuan[3];Yan, Deyue[1,3]

机构：[1]E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Adv Polymer Mat Shanghai, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2011

卷号：21

期号：35

起止页码：13611

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY

收录：;EI(收录号：20113514276629);WOS:【SCI-EXPANDED(收录号:WOS:000294176600065)】；

基金：This work was financially supported by Shanghai Natural Scientific Foundation of China (10ZR1409500). Support from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, and the financial support of the Shanghai Key Laboratory of Advanced Polymer Materials (ZD20100101), and Open Foundation of East China Normal University (ECNU2001-49) are also appreciated.

语种：英文

外文关键词：Lanthanum compounds - Targeted drug delivery - Crosslinking - Controlled drug delivery - Nanomagnetics - Acrylic monomers - Block copolymers - Superparamagnetism - Atom transfer radical polymerization - Dendrimers - Magnetite - Oleic acid

摘要：One route has been employed to prepare dendritic-linear block copolymer modified superparamagnetic iron oxide nanoparticles (SPIONs), which consist of a Fe(3)O(4) magnetic nanoparticle core and a dendritic-linear block copolymer, the focal point polyamidoamine-type dendron-b-poly(2-dimethylaminoethyl methacrylate)-b-poly(N-isopropylacrylamide) (PAMAM-b-PDMAEMA-b-PNIPAM) shell by two-step atom transfer radical polymerization (ATRP). Firstly, Fe(3)O(4) nanoparticles were prepared by a high-temperature solution phase reaction in the presence of iron(III) acetylacetonate [Fe(acac)(3)], oleic acid and oleylamine. Then propargyl focal point PAMAM-type dendron (generation 2.0, denoted as propargyl-D(2.0)) with four carboxyl acid end groups as a cap displaced the oleic acid and oleylamine on the surfaces. Subsequently, an initiator for ATRP was introduced onto the propargyl-D(2.0)-modified Fe(3)O(4) nanoparticle surfaces via click chemistry with 2'-azidoethyl-2-bromoisobutylate (AEBIB). PDMAEMA and PNIPAM were grown gradually from nanoparticle surfaces using two-step copper-mediated ATRP. Finally, a crosslinking reaction between PDMAEMA block with 1,2-bis(2-iodoethoxy) ethane (BIEE) was used to stabilize the nanoparticles and reverse aggregation. The modified nanoparticles were subjected to detailed characterization using FT-IR, DLS, XRD and TGA. Magnetization measurements confirmed the characteristic superparamagnetic behavior of all magnetic nanoparticles under room temperature. In addition, doxorubicin (DOX) as an anticancer drug model was loaded into the dendritic-linear block copolymer shell of the modified nanoparticles, and subsequently the drug release was performed in phosphoric acid buffer solution (pH 7.4) at 25 degrees C or 37 degrees C. The results verify that dendritic-linear block copolymer-modified nanoparticles as a drug carrier possess thermosensitive drug release behaviors. Furthermore, a methyl tetrazolium (MTT) assay of DOX-loaded dendritic-linear block copolymer-modified nanoparticles against Hela cells was evaluated. The results show that the modified nanoparticles can be used for drug delivery.