文献类型：期刊文献

英文题名：Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

作者：Li, Yulin[1,2];Zheng, Ling[1,2];Xiao, Lan[3,4];Wang, Liudi[1,2];Cui, Jingyuan[1,2];Sha, Dongyong[1,2];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Brisbane, Qld 4059, Australia;[4]Australia China Ctr Tissue Engn & Regenerat Med A, 60 Musk Ave, Brisbane, Qld 4059, Australia

年份：2020

卷号：8

期号：22

起止页码：6375

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20204709514088);WOS:【SCI-EXPANDED(收录号:WOS:000588260700016)】；

基金：The research was supported by the National Key R&D Program of China (2018YFE0201500 and 2017YFB0309300), the National Natural Science Foundation of China (81772317 and 51973060), the National Natural Science Foundation of China for Innovative Research Groups (51621002) and Frontiers Science Center for Materiobiology and Dynamic Chemistry. The funding grant from Shanghai International Cooperation Program (15520721200) was also acknowledged.

语种：英文

外文关键词：Disease control - Diseases - Phosphorus compounds - Precipitation (chemical) - Diagnosis - Graphene - Drug delivery - Nanostructured materials - Magnetic resonance - Tumors

摘要：Success in disease therapy depends on precision medicines, where development of formulations with diagnostic and therapeutic functions is quite important. In this study, multifunctional theranostics based on a magnetic graphene oxide (GO) nanohybrid (GIPD) has been developed for magnetic resonance (MR) imaging-guided chemo-photothermal therapy of cancer. The GIPD is endowed with T-1/T-2 MR imaging capacity via precipitation of small-sized IONP nanoparticles (8.25 +/- 2.25 nm) on GO nanosheets through a mild friendly way (60 degrees C for 1 h, no organic solvent). The obtained nanocomposite is then non-covalently decorated with phosphine oxide polyethylene glycol to improve biosafety. The final nanohybrid effectively loads doxorubicin as the model chemotherapeutic drug and is found to have in vivo T-1/T-2 MR bimodal imaging functions. Both the in vitro and in vivo results demonstrate that the GO-based nanoplatform displays a good remote photothermal effect, which can damage the dense shell of solid tumor tissue, thereby facilitating the delivery of anticancer drugs into tumor cells. Therefore, this theranostic nanoplatform enables a potent combined chemo-photothermal anticancer efficacy, holding great potential for exploitation of precision cancer therapy.