文献类型：期刊文献

英文题名：Novel Fabricating Process for Porous Polyglycolic Acid Scaffolds by Melt-Foaming Using Supercritical Carbon Dioxide

作者：Zhang, Jiapeng[1];Yang, Shengbing[2];Yang, Xi[3];Xi, Zhenhao[1,6];Zhao, Ling[1,6];Cen, Lian[1];Lu, Eryi[4];Yang, Ying[5]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Meilong Rd, Shanghai, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implant,Dept Orthopaed, 639 Zhizaoju Rd, Shanghai, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Med, Dept Stomatol, Renji Hosp, 160 Pujian Rd, Shanghai, Peoples R China;[5]Univ Keele, Inst Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England;[6]Shanghai Huaming Hitech Grp Co LTD, Natl Engn Res Ctr Ultrafine Powder, 1305 Huajing Rd, Shanghai, Peoples R China

年份：2018

卷号：4

期号：2

起止页码：694

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20180704802426);WOS:【SCI-EXPANDED(收录号:WOS:000425194500042)】；

基金：The authors are grateful to the National Key R&D Program of China (Grant No. 2016YFB0302200), the National Natural Science Foundation of China (Grant 21676083), the Shanghai Rising-Star Program (Grant 16QB140130), the Fundamental Research Funds for the Central Universities, and the 111 Project (B08021).

语种：英文

外文关键词：polyglycolic acid; high crystallinity; supercritical carbon dioxide foaming; new strategy; porous scaffold

摘要：Polyglycolic acid (PGA) is a biocompatible and biodegradable polymer with high crystallinity. It is difficult to obtain PGA porous scaffolds with controllable morphology as well as outstanding mechanical properties without toxic solvents. The current study thus aimed to develop a novel melt-foaming strategy to prepare porous PGA scaffolds through the interaction between PGA molecules and supercritical carbon dioxide (scCO(2)). Before the design of foaming strategy, rheological properties of PGA were first studied by a Haake rheometer, whereas the effect of scCO(2) on PGA was investigated by high-pressure differential scanning calorimetry (DSC). It was revealed that the elasticity and viscosity could be greatly improved by a temperature regulation operation to withstand the growth of bubbles at the initial depressurization. Meanwhile, the melting and crystallization temperatures of PGA were reduced because of the plasticization effect of scCO(2). Through the dissolution of compressed CO, into PGA melt and subsequent rapid depressurization at a relatively low temperature with high PGA melt strength, PGA scaffolds with porosity of 39-74%, average pore sizes ranging from 5 to 50 mu m, and interconnectivity greater than 90% could be controllably fabricated. The effect of foaming temperature and pressure on morphology of PGA foams were then examined in detail. Special nanoscale morphology on the pore surface of resultant porous PGA foams was observed. These PGA foams also exhibited attractive compressive modulus of 68-116 MPa. The PGA foams with 74% porosity and average pore size of 38 mu m, prepared at 208 degrees C and 20 MPa were then used as scaffolds for in vitro cellular evaluation. Fibroblasts seeded on the scaffold exhibited excellent spreading shape and good proliferation ability and in vivo implantation of PGA foams manifested as the notable tissue ingrowth and neovascularization process within the foams, ascertaining its potential applications for tissue engineering and regenerative medicine. This work presents a breakthrough to fabricate highly crystalline PGA into porous scaffolds instead of traditional fibrous ones.