文献类型：期刊文献

英文题名：Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

作者：Chen, Xinye[1];Yu, Yuanman[3];He, Zirui[2];Pan, Lina[2];Wang, Jing[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2025

卷号：12

期号：36

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20252718708216);WOS:【SCI-EXPANDED(收录号:WOS:001518990700001)】；

基金：This study was supported by the Key Program of the National Natural Science Foundation of China (No. 32230059), the Basic Science Center Program (No. T2288102), the National Natural Science Foundation of China (Nos. 32471406, 82472161, and 32101086), the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (no. JKVD1211002), and Key Research and Development Plan of Shandong Province (2023CXPT103), and the Wego Project of Chinese Academy of Sciences (No. (2020) 005).

语种：英文

外文关键词：cartilage regeneration; hydrogel microparticles; inflammatory modulation; osteoarthritis

摘要：Osteoarthritis (OA) is a typical degenerative disease characterized primarily by the degeneration of cartilage. However, current treatments for cartilage degeneration often lead to the formation of hypertrophic cartilage and fibrocartilage, making it challenging to achieve full-thickness cartilage. Here, dual-modular hydrogel microparticles (dmHMPs) are developed, which enable precise spatio-temporal modulation and dynamic equilibrium between immune responses and cartilage regeneration. dmHMPs can modulate the inflammatory microenvironment of the joint by promoting the polarization of synovial macrophages toward an anti-inflammatory phenotype. Consequently, as inflammation is mitigated, synovium-derived mesenchymal stem cells recruited by dmHMPs can efficiently undergo chondrogenic differentiation to repair damaged cartilage in situ. In vivo experiments demonstrate that dmHMPs significantly suppress the expression of Indian hedgehog (Ihh) and collagen type X, thereby reducing the formation of hypertrophic cartilage and preserving the structural integrity and biological functions of articular cartilage. This therapeutic modulates the dynamic balance between inflammation and repair, providing a promising approach for full-thickness cartilage regeneration.