文献类型：期刊文献

英文题名：Controllable preparation of SB-3CT loaded PLGA microcapsules for traumatic-brain-injury pharmaco-therapy

作者：Chen, Hong[1];Jia, Feng[2];Zhu, Chengcheng[1];Xu, Jumei[1];Hua, Xiaobin[1];Xi, Zhenhao[1];Shen, Liang[1];Zhao, Shicheng[1];Cen, Lian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Dept Prod Engn,State Key Lab Chem Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Renji Hosp, Sch Med, Dept Neurosurg, 1630 Dong Fang Rd, Shanghai, Peoples R China

年份：2018

卷号：339

起止页码：346

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20181404985063);WOS:【SCI-EXPANDED(收录号:WOS:000427619400038)】；

基金：This study is financially supported by National "973" Project Foundation (2010CB944804) and National Nature Science Foundation (81471855, 21676083), and "Open Funding Project of the State Key Laboratory of Bioreactor Engineering".

语种：英文

外文关键词：TBI; SB-3CT; PLGA; Encapsulation; Microfluidics

摘要：This study is to explore controllable preparation of poly (lactic-co-glycolic acid) (PLGA) microcapsules to load 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane (SB-3CT) for traumatic brain injury (TBI) pharmacological therapy. Capillary-based microfluidic method was proposed to prepare SB-3CT loaded PLGA microcapsules. Drug loading and release behavior of the corresponding PLGA microcapsules were evaluated and correlated with their degradation profile. The obtained PLGA microcapsules had a golf-featured morphology and high monodispersion. Precise control on the size and size distribution of the microcapsules could be achieved by varying the geometry of the capillary device and operation parameters to yield uniform and reproducible PLGA microcapsules in the range of 35-65 mu m. A high drug encapsulation efficiency of 99% within the obtained PLGA microcapsules with a releasing duration of around 50 d was ensured. Pharmacological therapy of TBI was tried by local injection of PLGA-SB-3CT suspension in rats at the trauma site after TBI. The protection on brain tissue upon administration was demonstrated by accelerated behavioral recovery (beam balance and beam walk latencies, and spatial memory ability) and reduction in the neuronal cell apoptosis in CA2 and hilus hippocampus as well as the injury cortical region. Hence, PLGA-SB-3CT could serve as a promising pharmaco-therapeutic option for TBI treatment.