成果/Result
- Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2被引量：151收藏
- 作者：Xiong, Rui Zhang, Leike Li, Shiliang Sun, Yuan Ding, Minyi Wang, Yong Zhao, Yongliang Wu, Yan Shang, Weijuan Jiang, Xiaming Shan, Jiwei Shen, Zihao Tong, Yi Xu, Liuxin Chen, Yu Liu, Yingle Zou, Gang Lavillete, Dimitri Zhao, Zhenjiang Wang, Rui Zhu, Lili Xiao, Gengfu Lan, Ke Li, Honglin Xu, Ke
- 机构：Wuhan Univ;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：PROTEIN & CELL 2020
- 关键词：de novopyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation
- Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway被引量：76收藏
- 作者：Wu, Guozhen Zhu, Lili Yuan, Xing Chen, Hao Xiong, Rui Zhang, Shoude Cheng, Hao Shen, Yunheng An, Huazhang Li, Tiejun Li, Honglin Zhang, Weidong
- 机构：Second Mil Med Univ;East China Univ Sci & Technol;Second Mil Med Univ;Second Mil Med Univ
- 来源：ANTIOXIDANTS & REDOX SIGNALING 2017
- 关键词：Nrf2 stroke Britanin keap1 ROS
- Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2被引量：69收藏
- 作者：Dai, Wenhao Jochmans, Dirk Xie, Hang Yang, Hang Li, Jian Su, Haixia Chang, Di Wang, Jiang Peng, Jingjing Zhu, Lili Nian, Yong Hilgenfeld, Rolf Jiang, Hualiang Chen, Kaixian Zhang, Leike Xu, Yechun Neyts, Johan Liu, Hong
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;Katholieke Univ Leuven;Chinese Acad Sci;Nanjing Univ Chinese Med
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S被引量：59收藏
- 作者：Li, Qiannan Zhang, Tao Li, Shiliang Tong, Linjiang Li, Junyu Su, Zhicheng Feng, Fang Sun, Deheng Tong, Yi Wang, Xia Zhao, Zhenjiang Zhu, Lili Ding, Jian Li, Honglin Xie, Hua Xu, Yufang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACS MEDICINAL CHEMISTRY LETTERS 2019
- 关键词：EGFR mutant inhibitor C797S
- Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein被引量：58收藏
- 作者：Wang, Lin Wu, Yan Yao, Sheng Ge, Huan Zhu, Ya Chen, Kun Chen, Wen-zhang Zhang, Yi Zhu, Wei Wang, Hong-yang Guo, Yu Ma, Pei-xiang Ren, Peng-xuan Zhang, Xiang-lei Li, Hui-qiong Ali, Mohammad A. Xu, Wen-qing Jiang, Hua-liang Zhang, Lei-ke Zhu, Li-li Ye, Yang Shang, Wei-juan Bai, Fang
- 机构：ShanghaiTech Univ;ShanghaiTech Univ;Chinese Acad Sci;Chinese Acad Sci;Chinese Acad Sci
- 来源：ACTA PHARMACOLOGICA SINICA 2022
- 关键词：SARS-CoV-2 natural products virtual screening spike protein protein-protein interaction modulators
- A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors被引量：57收藏
- 作者：Ren, Peng-xuan Shang, Wei-juan Yin, Wan-chao Ge, Huan Wang, Lin Zhang, Xiang-lei Li, Bing-qian Li, Hong-lin Xu, Ye-chun Xu, Eric H. Jiang, Hua-liang Zhu, Li-li Zhang, Lei-ke Bai, Fang
- 机构：ShanghaiTech Univ;ShanghaiTech Univ;Chinese Acad Sci;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2022
- 关键词：SARS-CoV-2 inhibitors RdRp host ribosome Virus RNA
- Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives被引量：54收藏
- 作者：Xu, Minghao Zhu, Junsheng Diao, Yanyan Zhou, Hongchang Ren, Xiaoli Sun, Deheng Huang, Jin Han, Dongmei Zhao, Zhenjiang Zhu, Lili Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Huzhou Teachers Coll;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2013
- Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes被引量：51收藏
- 作者：Li, Shiliang Xu, Hongling Cui, Shichao Wu, Fangshu Zhang, Youli Su, Mingbo Gong, Yinghui Qiu, Shaobing Jiao, Qian Qin, Chun Shan, Jiwei Zhang, Ming Wang, Jiawei Yin, Qiao Xu, Minghao Liu, Xiaofeng Wang, Rui Zhu, Lili Li, Jia Xu, Yufang Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor被引量：50收藏
- 作者：Li, Qiao Quan, Lina Lyu, Jiankun He, Zenghui Wang, Xia Meng, Jiajia Zhao, Zhenjiang Zhu, Lili Liu, Xiaofeng Li, Honglin
- 机构：East China Univ Sci & Technol
- 来源：ONCOTARGET 2016
- 关键词：immunotherapy human programmed death 1 peptide inhibitor protein-protein interactions (PPIs) de novo peptide design
- Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase被引量：47收藏
- 作者：Zhu, Junsheng Han, Le Diao, Yanyan Ren, Xiaoli Xu, Minghao Xu, Liuxin Li, Shiliang Li, Qiang Dong, Dong Huang, Jin Liu, Xiaofeng Zhao, Zhenjiang Wang, Rui Zhu, Lili Xu, Yufang Qian, Xuhong Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2015
- Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery被引量：40收藏
- 作者：Diao, Yanyan Liu, Dandan Ge, Huan Zhang, Rongrong Jiang, Kexin Bao, Runhui Zhu, Xiaoqian Bi, Hongjie Liao, Wenjie Chen, Ziqi Zhang, Kai Wang, Rui Zhu, Lili Zhao, Zhenjiang Hu, Qiaoyu Li, Honglin
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：NATURE COMMUNICATIONS 2023
- Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity被引量：37收藏
- 作者：Cui, Kunqiang Lu, Weiqiang Zhu, Lili Shen, Xu Huang, Jin
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2013
- 关键词：Helicobacter pylori Peptide deformylase Propolis Phenolic compounds Caffeic acid phenethyl ester
- Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation被引量：34收藏
- 作者：Hao, Yongjia Lyu, Jiankun Qu, Rong Tong, Yi Sun, Deheng Feng, Fang Tong, Linjiang Yang, Tingyuan Zhao, Zhenjiang Zhu, Lili Ding, Jian Xu, Yufang Xie, Hua Li, Honglin
- 机构：East China Univ Sci & Technol;Guizhou Univ Chinese Med;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2018
- Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein被引量：32收藏
- 作者：Li, Bingqian Wang, Lin Ge, Huan Zhang, Xianglei Ren, Penxuan Guo, Yu Chen, Wuyan Li, Jie Zhu, Wei Chen, Wenzhang Zhu, Lili Bai, Fang
- 机构：ShanghaiTech Univ;ShanghaiTech Univ;Imperial Coll London;East China Univ Sci & Technol;Nankai Univ
- 来源：FRONTIERS IN CHEMISTRY 2021
- 关键词：SARS-CoV-2 receptor sialic acid RBD domain spike protein
- Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes被引量：29收藏
- 作者：Li, Shiliang Qin, Chun Cui, Shichao Xu, Hongling Wu, Fangshu Wang, Jiawei Su, Mingbo Fang, Xiaoyu Li, Dan Jiao, Qian Zhang, Ming Xia, Chunmei Zhu, Lili Wang, Rui Li, Jia Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2019
- Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening被引量：25收藏
- 作者：Wang, Liyan Zhang, Shoude Zhu, Junsheng Zhu, Lili Liu, Xiaofeng Shan, Lei Huang, Jin Zhang, Weidong Li, Honglin
- 机构：E China Univ Sci & Technol;Second Mil Med Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2014
- 关键词：Falcipain-2 inhibitors Natural products Virtual screening Antimalarial drug
- Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity被引量：24收藏
- 作者：Li, Shiliang Luan, Guoqin Ren, Xiaoli Song, Wenlin Xu, Liuxin Xu, Minghao Zhu, Junsheng Dong, Dong Diao, Yanyan Liu, Xiaofeng Zhu, Lili Wang, Rui Zhao, Zhenjiang Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2015
- Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation被引量：23收藏
- 作者：Hao, Yongjia Wang, Xia Zhang, Tao Sun, Deheng Tong, Yi Xu, Yuqiong Chen, Haiyang Tong, Linjiang Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Ding, Jian Xie, Hua Xu, Yufang Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis被引量：23收藏
- 作者：Zeng, Fanxun Li, Shiliang Yang, Guantian Luo, Yating Qi, Tiantian Liang, Yingfan Yang, Tingyuan Zhang, Letian Wang, Rui Zhu, Lili Li, Honglin Xu, Xiaoyong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACTA PHARMACEUTICA SINICA B 2021
- 关键词：DHODH De novo pyrimidine biosynthesis DHODH inhibitors Acrylamide derivatives Rheumatoid arthritis
- Sliding-attention transformer neural architecture for predicting T cell receptor-antigen-human leucocyte antigen binding被引量：22收藏
- 作者：Feng, Ziyan Chen, Jingyang Hai, Youlong Pang, Xuelian Zheng, Kun Xie, Chenglong Zhang, Xiujuan Li, Shengqing Zhang, Chengjuan Liu, Kangdong Zhu, Lili Hu, Xiaoyong Li, Shiliang Zhang, Jie Zhang, Kai Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ;Shanghai Jiao Tong Univ;Fudan Univ;Zhengzhou Univ
- 来源：NATURE MACHINE INTELLIGENCE 2024
- 关键词：Antigens - Cytology
- Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA被引量：21收藏
- 作者：Bai, Fang Liu, Kangdong Li, Huiliang Wang, Jiawei Zhu, Junsheng Hao, Pei Zhu, Lili Zhang, Shoude Shan, Lei Ma, Weiya Bode, Ann M. Zhang, Weidong Li, Honglin Dong, Zigang
- 机构：Dalian Univ Technol;East China Univ Sci & Technol;Rice Univ;Zhengzhou Univ;Collaborat Innovat Ctr Henan Prov Canc Chemopreve
- 来源：NUCLEIC ACIDS RESEARCH 2018
- Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors被引量：20收藏
- 作者：Dou, Dou Wang, Jie Qiao, Yunjin Wumaier, Gulinuer Sha, Wenjie Li, Wenjie Mei, Wenyi Yang, Tingyuan Zhang, Chen He, Huan Wang, Caolin Chu, Linna Sun, Baihui Su, Rongrong Ma, Xiangyu Gong, Mengdie Xie, Lijuan Jiang, Wenzhe Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：4-Anilinoquinazoline Non-small cell lung cancer (NSCLC) Epidermal growth factor receptor (EGFR) Kinase inhibitor Anti-proliferative activity
- Discovery of natural estrogen receptor modulators with structure-based virtual screening被引量：20收藏
- 作者：Cao, Xianwen Jiang, Jing Zhang, Shoude Zhu, Lili Zou, Juan Diao, Yanyan Xiao, Weilie Shan, Lei Sun, Handong Zhang, Weidong Huang, Jin Li, Honglin
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Chinese Acad Sci;Second Mil Med Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2013
- 关键词：Molecular docking Natural product Estrogen receptor Virtual screening
- Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2被引量：19收藏
- 作者：Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu
- 机构：State Key Laboratory of Virology;Shanghai Key Laboratory of New Drug Design;State Key Laboratory of Virology;CAS Key Laboratory of Molecular Virology and Immunology
- 来源：蛋白质与细胞（英文版） 2020
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- In Vitro Human Dihydroorotate Dehydrogenase Inhibitory, Anti-inflammatory and Cytotoxic Activities of Alkaloids from the Seeds of Nigella glandulifera被引量：18收藏
- 作者：Gao, Jun-Bo Zhang, Xing-Jie Zhang, Rui-Han Zhu, Li-Li Pu, De-Bing Li, Xiao-Li Li, Hong-Lin Xu, Min Xiao, Wei-Lie
- 机构：Chinese Acad Sci;Yunnan Univ;Yunnan Univ;Southeast Univ;East China Univ Sci & Technol
- 来源：PLANTA MEDICA 2018
- 关键词：dolabellane-type diterpene alkaloids Ranunculaceae Nigella glandulifera human dihydroorotate dehydrogenase lipopolysaccharide nitric oxide production cytotoxic activity
- A three-dimensional (3D) liver-kidney on a chip with a biomimicking circulating system for drug safety evaluation被引量：15收藏
- 作者：Huang, Qihong Yang, Tianhao Song, Yunpeng Sun, Wenxuan Xu, Jian Cheng, Ya Yin, Ruixue Zhu, Lili Zhang, Mengting Ma, Lei Li, Honglin Zhang, Hongbo
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol
- 来源：LAB ON A CHIP 2024
- 关键词：Animals - Cell culture - Drug products - Etching - Metabolism - Metabolites - Ultrafast lasers
- Synthesis, Design, and Structure-Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase被引量：15收藏
- 作者：Xu, Le Li, Wenjie Diao, Yanyan Sun, Hongxia Li, Honglin Zhu, Lili Zhou, Hongchang Zhao, Zhenjiang
- 机构：East China Univ Sci & Technol;Huzhou Teachers Coll
- 来源：MOLECULES 2018
- 关键词：P. falciparum PfDHODH pyrimidone antimalarial agents
- Design, synthesis and structure-activity relationship study of aminopyridine derivatives as novel inhibitors of Janus kinase 2被引量：14收藏
- 作者：Wang, Wanqi Diao, Yanyan Li, Wenjie Luo, Yating Yang, Tingyuan Zhao, Yuyu Qi, TianTian Xu, Fangling Ma, Xiangyu Ge, Huan Liang, Yingfan Zhao, Zhenjiang Liang, Xin Wang, Rui Zhu, Lili Li, Honglin Xu, Yufang
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2019
- 关键词：JAK2 Rheumatoid arthritis Crizotinib Molecular docking
- Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents被引量：13收藏
- 作者：Song, Wenlin Li, Shiliang Tong, Yi Wang, Jiawei Quan, Lina Chen, Zhuo Zhao, Zhenjiang Xu, Yufang Zhu, Lili Qian, Xuhong Li, Honglin
- 机构：East China Univ Sci & Technol
- 来源：MEDCHEMCOMM 2016
- Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors被引量：13收藏
- 作者：Yuan, Zhen Chen, Xingyu Fan, Sisi Chang, Longfeng Chu, Linna Zhang, Ying Wang, Jie Li, Shuang Xie, Jinxin Hu, Jianguo Miao, Runyu Zhu, Lili Zhao, Zhenjiang Li, Honglin Li, Shiliang
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
- 关键词：binding free energy fragment molecular orbital method SHP2
