成果/Result
- Chemical biotechnology for plant protection被引量：157收藏
- 作者：Zhao, Zhenjiang Xu, Yufang Qian, Xuhong
- 机构： Shanghai Key Laboratory of New Drug Design; Shanghai Key Laboratory of Chemical Biology
- 来源：RSC Green Chemistry 2015
- Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2被引量：151收藏
- 作者：Xiong, Rui Zhang, Leike Li, Shiliang Sun, Yuan Ding, Minyi Wang, Yong Zhao, Yongliang Wu, Yan Shang, Weijuan Jiang, Xiaming Shan, Jiwei Shen, Zihao Tong, Yi Xu, Liuxin Chen, Yu Liu, Yingle Zou, Gang Lavillete, Dimitri Zhao, Zhenjiang Wang, Rui Zhu, Lili Xiao, Gengfu Lan, Ke Li, Honglin Xu, Ke
- 机构：Wuhan Univ;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：PROTEIN & CELL 2020
- 关键词：de novopyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation
- Chemical bioengineering in plant cell culture被引量：121收藏
- 作者：Hu, Fengxian Xu, Yufang Zhao, Zhenjiang
- 机构： School of Biotechnology; Shanghai Key Laboratory of New Drug Design
- 来源：RSC Green Chemistry 2015
- SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors To Suppress cell Migration被引量：71收藏
- 作者：Lu, Weiqiang Liu, Xiaofeng Cao, Xianwen Xue, Mengzhu Liu, Kangdong Zhao, Zhenjiang Shen, Xu Jiang, Hualiang Xu, Yufang Huang, Jin Li, Honglin
- 机构：Zhengzhou Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2011
- Design and development of novel EGFR inhibitors spanning all subgroups of EGFR mutations in non-small cell lung cancer被引量：70收藏
- 作者：Wang, Caolin Cen, Yiting Zhang, Manzhan Tang, Jiahong Yan, Zitong Xie, Lijuan Sun, Deheng Zhou, Wei Wang, Jie Yu, Panpan Yuan, Zhen Wang, Junyi Hu, Zeyan Yang, Tingyuan Sha, Wenjie Li, Shiliang Zhao, Zhenjiang Xu, Yufang Chen, Zhuo Li, Honglin
- 机构： School of Pharmacy; Innovation Center for AI and Drug Discovery
- 来源：Innovation 2026
- 关键词：Binding sites - Biological organs - Design for testability - Diagnosis - Lung cancer - Medical applications - Metabolism - Structural optimization
- Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand Simultaneous Docking (MLSD): Identifying celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)被引量：68收藏
- 作者：Li, Huameng Liu, Aiguo Zhao, Zhenjiang Xu, Yufang Lin, Jiayuh Jou, David Li, Chenglong
- 机构：Ohio State Univ;Ohio State Univ;Nationwide Childrens Hosp;Huazhong Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2011
- Novel Benzo-1,2,3-thiadiazole-7-carboxylate Derivatives As Plant Activators and the Development of Their Agricultural Applications被引量：63收藏
- 作者：Du, Qingshan Zhu, Weiping Zhao, Zhenjiang Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2012
- 关键词：benzo-1,2,3-thiadiazole-7-carboxylate derivatives system acquired resistance plant activator field test
- Discovery of Pteridin-7(8H)-one-Based Irreversible Inhibitors Targeting the Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R Mutant被引量：63收藏
- 作者：Zhou, Wei Liu, Xiaofeng Tu, Zhengchao Zhang, Lianwen Ku, Xin Bai, Fang Zhao, Zhenjiang Xu, Yufang Ding, Ke Li, Honglin
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;Tech Univ Munich;Dalian Univ Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2013
- Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S被引量：59收藏
- 作者：Li, Qiannan Zhang, Tao Li, Shiliang Tong, Linjiang Li, Junyu Su, Zhicheng Feng, Fang Sun, Deheng Tong, Yi Wang, Xia Zhao, Zhenjiang Zhu, Lili Ding, Jian Li, Honglin Xie, Hua Xu, Yufang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACS MEDICINAL CHEMISTRY LETTERS 2019
- 关键词：EGFR mutant inhibitor C797S
- Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism被引量：57收藏
- 作者：Qian, Zhi-Gang Zhao, Zhen-Jiang Xu, Yufang Qian, Xuhong Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Dalian Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2004
- 关键词：plant cell culture Taxus chinensis synthetic jasmonate derivatives inducing signal secondary metabolism plant defense response
- Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives被引量：54收藏
- 作者：Xu, Minghao Zhu, Junsheng Diao, Yanyan Zhou, Hongchang Ren, Xiaoli Sun, Deheng Huang, Jin Han, Dongmei Zhao, Zhenjiang Zhu, Lili Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Huzhou Teachers Coll;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2013
- Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes被引量：51收藏
- 作者：Li, Shiliang Xu, Hongling Cui, Shichao Wu, Fangshu Zhang, Youli Su, Mingbo Gong, Yinghui Qiu, Shaobing Jiao, Qian Qin, Chun Shan, Jiwei Zhang, Ming Wang, Jiawei Yin, Qiao Xu, Minghao Liu, Xiaofeng Wang, Rui Zhu, Lili Li, Jia Xu, Yufang Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor被引量：50收藏
- 作者：Li, Qiao Quan, Lina Lyu, Jiankun He, Zenghui Wang, Xia Meng, Jiajia Zhao, Zhenjiang Zhu, Lili Liu, Xiaofeng Li, Honglin
- 机构：East China Univ Sci & Technol
- 来源：ONCOTARGET 2016
- 关键词：immunotherapy human programmed death 1 peptide inhibitor protein-protein interactions (PPIs) de novo peptide design
- Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase被引量：47收藏
- 作者：Zhu, Junsheng Han, Le Diao, Yanyan Ren, Xiaoli Xu, Minghao Xu, Liuxin Li, Shiliang Li, Qiang Dong, Dong Huang, Jin Liu, Xiaofeng Zhao, Zhenjiang Wang, Rui Zhu, Lili Xu, Yufang Qian, Xuhong Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2015
- Insulin-like Growth Factor-1 Receptor (IGF-1R) Kinase Inhibitors in Cancer Therapy: Advances and Perspectives被引量：45收藏
- 作者：Xue, Mengzhu Cao, Xianwen Zhong, Ye Kuang, Dong Liu, Xiaofeng Zhao, Zhenjiang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：CURRENT PHARMACEUTICAL DESIGN 2012
- 关键词：Receptor tyrosine kinase IGF-1R IR EGFR small molecule inhibitors anticancer strategies signaling transduction pathway network pharmacology
- Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening被引量：41收藏
- 作者：Diao, Yanyan Lu, Weiqiang Jin, Huangtao Zhu, Junsheng Han, Le Xu, Minghao Gao, Rui Shen, Xu Zhao, Zhenjiang Liu, Xiaofeng Xu, Yufang Huang, Jin Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery被引量：40收藏
- 作者：Diao, Yanyan Liu, Dandan Ge, Huan Zhang, Rongrong Jiang, Kexin Bao, Runhui Zhu, Xiaoqian Bi, Hongjie Liao, Wenjie Chen, Ziqi Zhang, Kai Wang, Rui Zhu, Lili Zhao, Zhenjiang Hu, Qiaoyu Li, Honglin
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：NATURE COMMUNICATIONS 2023
- Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate被引量：39收藏
- 作者：Wang, Wei Zhao, Zhen-Jiang Xu, Yufang Qian, Xuhong Zhong, Jian-Jiang
- 机构： State Key Laboratory of Bioreactor Engineering; School of Pharmacy; Shanghai Key Laboratory of Chemical Biology
- 来源：Applied Microbiology and Biotechnology 2006
- 关键词：Ammonia - Biosynthesis - Biotechnology - Carboxylic acids - cells - Microbiology
- Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation被引量：34收藏
- 作者：Hao, Yongjia Lyu, Jiankun Qu, Rong Tong, Yi Sun, Deheng Feng, Fang Tong, Linjiang Yang, Tingyuan Zhao, Zhenjiang Zhu, Lili Ding, Jian Xu, Yufang Xie, Hua Li, Honglin
- 机构：East China Univ Sci & Technol;Guizhou Univ Chinese Med;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2018
- Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes被引量：29收藏
- 作者：Li, Shiliang Qin, Chun Cui, Shichao Xu, Hongling Wu, Fangshu Wang, Jiawei Su, Mingbo Fang, Xiaoyu Li, Dan Jiao, Qian Zhang, Ming Xia, Chunmei Zhu, Lili Wang, Rui Li, Jia Jiang, Hualiang Zhao, Zhenjiang Li, Jingya Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2019
- Discovery of novel selective inhibitors for EGFR-T790M/L858R被引量：28收藏
- 作者：Bai, Fang Liu, Hongyan Tong, Linjiang Zhou, Wei Liu, Li Zhao, Zhenjiang Liu, Xiaofeng Jiang, Hualiang Wang, Xicheng Xie, Hua Li, Honglin
- 机构：Dalian Univ Technol;Dalian Univ Technol;Chinese Acad Sci;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2012
- 关键词：EGFR T790M/L858R Virtual screening Kinase inhibitors Selective inhibitors Dual-effective inhibitors
- Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants被引量：27收藏
- 作者：Sun, Deheng Yang, Yu Lyu, Jiankun Zhou, Wei Song, Wenlin Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis被引量：25收藏
- 作者：Zhong, Ye Xue, Mengzhu Zhao, Xue Yuan, Jun Liu, Xiaofeng Huang, Jin Zhao, Zhenjiang Li, Honglin Xu, Yufang
- 机构：E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2013
- 关键词：RSK2 Kinase inhibitor Molecular docking
- From chemical biology to its technology and engineering被引量：25收藏
- 作者：Qian, Xuhong Zhao, Zhenjiang Xu, Jian-He Xu, Yufang Zhang, Yi-Heng Percival Hu, Fengxian Zhang, Jingyan Yong, Yang-Chun
- 机构： Shanghai Key Laboratory of Chemical Biology; Shanghai Key Laboratory of New Drug Design; Laboratory of Biocatalysis and Synthetic Biotechnology; Cell Free Bioinnovations Inc.; School of Biotechnology
- 来源：RSC Green Chemistry 2015
- Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation被引量：24收藏
- 作者：Su, Zhicheng Yang, Tingyuan Wang, Jie Lai, Mengzhen Tong, Linjiang Wumaier, Gulinuer Chen, Zhuo Li, Shengqing Li, Honglin Xie, Hua Zhao, Zhenjiang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ;Fudan Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2020
- 关键词：EGFR NSCLC C797S
- Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity被引量：24收藏
- 作者：Li, Shiliang Luan, Guoqin Ren, Xiaoli Song, Wenlin Xu, Liuxin Xu, Minghao Zhu, Junsheng Dong, Dong Diao, Yanyan Liu, Xiaofeng Zhu, Lili Wang, Rui Zhao, Zhenjiang Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2015
- Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation被引量：23收藏
- 作者：Hao, Yongjia Wang, Xia Zhang, Tao Sun, Deheng Tong, Yi Xu, Yuqiong Chen, Haiyang Tong, Linjiang Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Ding, Jian Xie, Hua Xu, Yufang Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors被引量：20收藏
- 作者：Dou, Dou Wang, Jie Qiao, Yunjin Wumaier, Gulinuer Sha, Wenjie Li, Wenjie Mei, Wenyi Yang, Tingyuan Zhang, Chen He, Huan Wang, Caolin Chu, Linna Sun, Baihui Su, Rongrong Ma, Xiangyu Gong, Mengdie Xie, Lijuan Jiang, Wenzhe Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：4-Anilinoquinazoline Non-small cell lung cancer (NSCLC) Epidermal growth factor receptor (EGFR) Kinase inhibitor Anti-proliferative activity
- Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-Based Virtual Screening with the Inhibitor-Constrained Refined Homology Model被引量：20收藏
- 作者：Li, Shiliang Zhou, Yi Lu, Weiqiang Zhong, Ye Song, Wenlong Liu, Kangdong Huang, Jin Zhao, Zhenjiang Xu, Yufang Liu, Xiaofeng Li, Honglin
- 机构：E China Univ Sci & Technol;Zhengzhou Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Virtual reality - Crystal structure - Digital libraries - Amino acids - Binding sites - Diseases
- Design, synthesis and evaluation of PPAR gamma binding activity of 2-thioxo-4-thiazolidinone derivatives被引量：19收藏
- 作者：Zhou, Li Zhong, Ye Xue, Meng-Zhu Kuang, Dong Cao, Xian-Wen Zhao, Zhen-Jiang Li, Hong-Lin Xu, Yu-Fang Wang, Rui
- 机构：E China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2015
- 关键词：2-Thioxo-4-thiazolidinone Peroxisome proliferator activated receptor gamma Binding activities SAR Molecular docking
