成果/Result
- Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression被引量：92收藏
- 作者：Luo, Chubin Xin, Haoyang Zhou, Zhengjun Hu, Zhiqiang Sun, Rongqi Yao, Na Sun, Qiman Borjigin, Uyunbilig Wu, Xia Fan, Jia Huang, Xiaowu Zhou, Shaolai Zhou, Jian
- 机构：Fudan Univ;Fudan Univ;Inner Mongolia Univ;East China Univ Sci & Technol;Fudan Univ
- 来源：HEPATOLOGY 2022
- Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways被引量：13收藏
- 作者：Zhong, Chen Jiang, Wei Wang, Yefan Sun, Junjiang Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2022
- 关键词：CTLA4-Ig CD40-Ig AAV multiple systemic administration immune tolerance
- Dynamic changes of histone acetylation and methylation in bovine oocytes, zygotes, and preimplantation embryos被引量：12收藏
- 作者：Wu, Xia Hu, Shuxiang Wang, Lingling Li, Yan Yu, Haiquan
- 机构：East China Univ Sci & Technol;Inner Mongolia Univ
- 来源：JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION 2020
- 关键词：fertilization histone acetylation histone methylation oocyte meiosis preimplantation development
- Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways被引量：9收藏
- 作者：Zhong, Chen Chen, Zifeng Xia, Yong Wu, Jun Zhang, Feixu Cheng, Cheng Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina
- 来源：MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT 2022
- Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models被引量：6收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Li, Xinting Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GENE THERAPY 2025
- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer被引量：5收藏
- 作者：Tao, Deyou Liang, Junqing Pan, Yihong Zhou, Yanting Feng, Ying Zhang, Lin Xu, Jingjing Wang, Hui He, Ping Yao, Jie Zhao, Yang Ning, Qinjie Wang, Wen Jiang, Wei Zheng, Jing Wu, Xia
- 机构：Taizhou Enze Med Grp;Inner Mongolia Med Univ;Gynecol Taizhou Enze Med Ctr Grp Enze Hosp;East China Univ Sci & Technol
- 来源：JOURNAL OF BREAST CANCER 2019
- 关键词：Breast neoplasms Disease progression LAPTM4B protein human MCF-7 cells
- Prevention of Portal-Tract Fibrosis in Zfyve19-/- Mouse Model with Adeno-Associated Virus Vector Delivering ZFYVE19被引量：4收藏
- 作者：Zhang, Yanan Tang, Dingyue Wang, Li Yang, Jing Wu, Xia Xiao, Xiao Wang, Jian-She
- 机构：Fudan Univ;Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Key Lab Birth Defect
- 来源：HUMAN GENE THERAPY 2023
- 关键词：AAV gene therapy mouse model portal-tract fibrosis ZFYVE19
- BDNF gene therapy rescues neuronal function via unique and common transcriptional responses in Aβ and tau-driven Alzheimer's disease mouse models被引量：4收藏
- 作者：Tang, Siqi Luo, Wenshu Cheng, Cheng Shen, Leshan Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;East China Univ Sci & Technol;Shanghai Belief Biomed Inc
- 来源：BIOCHEMISTRY AND BIOPHYSICS REPORTS 2025
- 关键词：BDNF Gene therapy Alzheimer's disease RNA-Seq analysis rTg4510 APP/PS1
- Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways被引量：3收藏
- 作者：Wu, Jiamei Zhao, Kai Du, Zengmin Chen, Ying Zhang, Feixu Jiang, Wei Zheng, Jing Wu, Xia Shen, Chengyong Xiao, Xiao
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer's disease in multiple mouse models被引量：3收藏
- 作者：Tang, Siqi Luo, Wenshu Wu, Shihao Yuan, Meng Wen, Jiashuo Zhong, Guoshen Shen, Leshan Jiang, Wei Cheng, Cheng Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;Yunnan Univ;East China Univ Sci & Technol
- 来源：GENES & DISEASES 2026
- 关键词：AAVT42 Alzheime's disease Brain-derived neurotrophic factor Cognitive impairment Hippocampal RNA sequencing
- Prevalence of neutralizing antibodies against AAV8, AAV9, and AAV843 in a Chinese population被引量：3收藏
- 作者：Xu, Jingjing Zhang, Jingyu Xin, Lei Yang, Chen Zhang, Feixu Tang, Siqi Yao, Jie Wang, Hui Ning, Qinjie Yan, Mendi Li, Min Wu, Jiamei Chen, Ying Zhong, Chen Zhou, Kaiyi Du, Zengmin Jiang, Wei Wu, Xia Yang, Youjun Sun, Junjiang Xiao, Xiao Zheng, Jing
- 机构：East China Univ Sci & Technol;Harbin Med Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2019
- 关键词：Neutralizing antibodies adeno-associated virus prevalence gene therapy
- AAV介导的TNFR关节内基因治疗对血友病性关节病预防和治疗的实验研究被引量：2收藏
- 作者：林振洋 王冶凡 张飞旭 周新月 宗晓莹 吴侠 华宝来 肖啸 孙君江
- 机构：华东理工大学药学院;华东理工大学生物工程学院;国家生物器反应工程重点实验室;徐州医科大学扬州临床学院;扬州大学临床医学院血液科
- 来源：《华东理工大学学报（自然科学版）》 2022
- 关键词：血友病性关节病 sTNFR 腺相关病毒(AAV) 关节内注射 基因治疗
- 摘要：血友病性关节病(HA)的发病机制与关节内炎性细胞因子过表达有关,肿瘤坏死因子α(TNFα)是最重要的炎性因子之一。可溶性肿瘤坏死因子受体(sTNFR)作为TNFα的受体可以特异性地与TNFα结合拮抗TNFα炎性效应。为探...
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- 基于KRAS突变肽段介导的胰腺癌免疫治疗被引量：2收藏
- 作者：贺心怡 汤丁越 张洁 丁浩 吴侠
- 机构：华东理工大学药学院;华东理工大学生物工程学院
- 来源：《华东理工大学学报(自然科学版)》 2025
- 关键词：胰腺导管癌 KRAS 免疫疗法 腺病毒 基因治疗
- 摘要：通过增加KRAS抗原负荷来增强机体主动免疫,开发了一种KRAS靶向的免疫治疗药物。构建了Ad-SNP1、Ad-SNP2、Ad-SNP3和Ad-SNP4这4种质粒表达载体,每种载体含有的突变肽段种类、数量、排列顺序以及连接...
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- 来那度胺对血友病性关节炎的治疗作用研究被引量：2收藏
- 作者：王冶凡 林振洋 张飞旭 周新月 吴侠 肖啸 孙君江 华宝来
- 机构：华东理工大学药学院;华东理工大学生物反应器工程国家重点实验室;徐州医科大学扬州临床学院;扬州大学临床医学院血液科
- 来源：《中国实验血液学杂志》 2022
- 关键词：来那度胺 血友病性关节炎 人滑膜成纤维细胞 炎性因子 小鼠
- 摘要：目的:探讨来那度胺对人滑膜成纤维细胞(HFLS)增殖的影响以及对A型血友病小鼠血友病性关节炎(HA)的治疗效果。方法:以HFLS为模型细胞,在细胞培养基中添加柠檬酸铁和TNF-α重组蛋白,体外模拟炎性环境,加入不同浓度的...
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- 人体肝脏靶向性新型AAV血清型载体的研发被引量：1收藏
- 作者：宁秦洁 陈颖 闫梦迪 胡泽岚 吴侠 杜增民 郑静 肖啸
- 机构：华东理工大学药学院
- 来源：《华东理工大学学报（自然科学版）》 2020
- 关键词：腺相关病毒(AAV) 基因治疗 新型AAV血清型 DNA shuffling 靶向 肝脏细胞
- 摘要：通过DNA shuffling技术选择8种AAV(AAV1~AAV4,AAV6~AAV9)cap基因序列进行cap基因的DNA改组,获得AAV突变体基因库。将突变体基因库插入到含有AAV2Rep基因和ITR序列的质粒中,...
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- Sildenafil increases AAV9 transduction after a systemic administration and enhances AAV9-dystrophin therapeutic effect in mdx mice被引量：1收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Zong, Xiaoying Li, Zhanao Tang, Dingyue Zhou, Lichen Zheng, Jing Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Gen Hosp Western Theater Command PLA;Belief BioMed;Univ N Carolina
- 来源：GENE THERAPY 2024
- 基于AFP靶点的肝细胞癌的免疫治疗研究被引量：1收藏
- 作者：张洁 汤丁越 王成烨 高雅文 徐文青 刘思雅 肖啸 吴侠
- 机构：华东理工大学生物工程学院;华东理工大学药学院
- 来源：《华东理工大学学报(自然科学版)》 2025
- 关键词：肝细胞癌 AFP 免疫疗法 腺病毒 治疗性肿瘤疫苗
- 摘要：甲胎蛋白(AFP)在大约70%~80%的肝细胞癌患者中表达,可作为肝细胞癌免疫治疗的靶点。目前大多以AFP为靶点的肿瘤疫苗的临床实验效果欠佳,因此急需开发一种更有效的、基于AFP抗原的治疗性肿瘤疫苗。以复制缺陷型腺病毒为...
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- Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice被引量：1收藏
- 作者：Zhang, Feixu Zhou, Xinyue Hua, Baolai He, Xinyi Li, Zhanao Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ
- 来源：GENE THERAPY 2024
- 新型肌肉高效亲和AAV血清型的开发被引量：0收藏
- 作者：陈颖 吴佳梅 凌菲香 曾步兵 郑静 吴侠 赵锴 肖啸
- 机构：华东理工大学药学院
- 来源：《华东理工大学学报（自然科学版）》 2022
- 关键词：基因治疗 腺相关病毒 定向改造 肽展示 肌肉亲和性
- 摘要：通过在AAV5衣壳的N573后插入一个寡肽PGPSPAD生成了一种改良的AAV血清型,称为AAVc1,它在体外和体内均表现出比AAV5、AAV8和AAV9更好的肌肉感染性;恒河猴血清中针对AAVc1的中和抗体(Neutr...
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- Novel AAV843 Vector-Mediated Gene Replacement Therapy Rescues Primary Hyperoxaluria Type I in Mice被引量：0收藏
- 作者：Zhang, Jingjia Yin, Ye Ji, Baowei Sun, Manqing Jiang, Yuanyan Wu, Xiaohui Xiao, Xiao Shen, Qian Wu, Xia Xu, Hong
- 机构：Fudan Univ;Shanghai Kidney Dev & Pediat Kidney Dis Res Ctr;Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CELLS 2026
- 关键词：primary hyperoxaluria type I gene replacement therapy AAV843 kidney injury
- 靶向心肌组织的新型腺相关病毒载体的构建及筛选被引量：0收藏
- 作者：陈晨 杜增民 吴侠 蒋威 赵阳 肖啸 郑静
- 机构：华东理工大学药学院
- 来源：《华东理工大学学报（自然科学版）》 2021
- 关键词：DNA shuffling 腺相关病毒 体内筛选 心肌 靶向
- 摘要：为了构建以心肌为靶点的基因治疗载体,通过DNA shuffling技术对选择的8种AAV(AAV1~AAV4,AAV6~AAV9)衣壳基因进行了重组,构建了随机突变体AAV衣壳文库。将随机突变体AAV衣壳文库在小鼠体内直...
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- Prophylaxis CTLA4-ig reduces anti-AAV neutralizing antibodies in AAV gene therapy for hemophilia被引量：0收藏
- 作者：Yu, Dandan Xu, Bingqi Liu, Wei Xue, Feng Chen, Yunfei Liu, Xiaofan Ju, Mankai Ting, Sun Dai, Xinyue Dong, Huan Gu, Wenjing Yang, Renchi Xiao, Xiao Wu, Xia Pei, Xiaolei Zhang, Lei
- 机构：Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BLOOD 2025
- Safety and Efficacy of Dalnacogene Ponparvovec (BBM-H901) in Moderate to Severe Adult Hemophilia B Participants: Long Term Follow-Up Data in an Early Phase Pilot Study被引量：0收藏
- 作者：Xue, Feng Zhang, Lei Xiao, Xiao Wu, Xia Sun, Yujie
- 机构：Chinese Acad Med Sci;Ctr Diag & Treatment Thrombosis & Hemostasis;Belief Med Technol Shanghai Co Ltd;East China Univ Sci & Technol;Takeda China Int Trading Co
- 来源：HAEMOPHILIA 2026
- 关键词：BBM-H901 gene therapy Hemophilia B
- Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer's disease in multiple mouse models被引量：0收藏
- 作者：Siqi Tang Wenshu Luo Shihao Wu Meng Yuan Jiashuo Wen Guoshen Zhong Leshan Shen Wei Jiang Cheng Cheng Xia Wu Xiao Xiao
- 机构：School of Pharmacy;Belief Biomed Inc;School of Medicine;School of Bioengineering
- 来源：基因与疾病(英文) 2026
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