成果/Result
- Nitazoxanide,an anti-parasitic drug,efficiently ameliorates learning and memory impairments in AD model mice被引量：6收藏
- 作者：Lei Fan Xiao-xia Qiu Zhi-yuan Zhu Jian-lu Lv Jian Lu Fei Mao Jin Zhu Jia-ying Wang Xiao-wei Guan Jing Chen Jin Ren Ji-ming Ye Yong-hua Zhao Jian Li Xu Shen
- 机构：Center for Drug Safety Evaluation and Research;University of Chinese Academy of Sciences;Shanghai Key Laboratory of New Drug Design;School of Medicine and Life Sciences;School of Health and Biomedical Sciences
- 来源：中国药理学报（英文版） 2019
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- Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway被引量：5收藏
- 作者：Jinlian Wei Xin Chen Yongyun Li Ruoxi Li Keting Bao Liang Liao Yuqing Xie Tiannuo Yang Jin Zhu Fei Mao Shuaishuai Ni Renbing Jia Xiaofang Xu Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;Department of Ophthalmology;Cancer Institute;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan;Clinical Medicine Scientific and Technical Innovation Center
- 来源：药学学报（英文版） 2022
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- Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease被引量：2收藏
- 作者：Xiaokang Li Jian Lu Yixiang Xu Jiaying Wang Xiaoxia Qiu Lei Fan Baoli Li Wenwen Liu Fei Mao Jin Zhu Xu Shen Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;School of Medicine and Life Sciences;Center for Drug Safety Evaluation and Research
- 来源：药学学报（英文版） 2020
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- Discovery of synergistic activity of fluoroquinolones in combination with antimicrobial peptides against clinical polymyxin-resistant Pseudomonas aeruginosa DK2被引量：2收藏
- 作者：Xinyu Zheng Qiao Cao Qin Cao Fei Mao Xiaokang Li Jin Zhu Lefu Lan Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;State Key Laboratory of Drug Research
- 来源：中国化学快报（英文版） 2020
- 关键词：Polymyxin B Pseudomonas aeruginosa Fluoroquinolones Synergy Cystic fibrosis Antimicrobial peptides
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- Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents被引量：1收藏
- 作者：Ruoxi Li Dazheng Ling Tongke Tang Zhenghui Huang Manjiong Wang Fei Mao Jin Zhu Lubin Jiang Jian Li Xiaokang Li
- 机构：State Key Laboratory of Bioreactor Engineering;Key Laboratory of Molecular Virology and Immunology;College of Pharmacy and Chemistry;Frontiers Science Center for Materiobiology and Dynamic Chemistry;School of Life Science and Technology
- 来源：中国化学快报（英文版） 2021
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- DPPA催化芴-9-羧酸的新颖脱羧反应被引量：0收藏
- 作者：丛晓丽 倪帅帅 朱进
- 机构：华东理工大学药学院;民生药业滨江分公司
- 来源：《化学试剂》 2012
- 关键词：芴-9-羧酸 脱羧反应 DPPA
- 摘要：以0.096 mmol叠氮磷酸二苯酯(Diphenylphosphorazidate,DPPA)为催化剂,在极性溶剂和0.48 mmol的三乙胺存在的条件下,0.48 mmol芴-9-羧酸可以发生新颖的脱羧反应。考察了水...
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- Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation被引量：0收藏
- 作者：Wenhua Chen Xue Yao Zhenghui Huang Fei Mao Longfei Guan Yun Tang Hualiang Jiang Jian Li Jin Huang Lubin Jiang Jin Zhu
- 机构：Shanghai Key Laboratory of New Drug Design;Key Laboratory of Molecular Virology & Immunology
- 来源：中国化学快报（英文版） 2019
- 关键词：Antimalarial drug Plasmodium falciparum FP-2 PfDHFR Dual inhibitor
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- Discovery and synthesis of N^2,N^4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first examples of small-molecular FGFR-1 activator被引量：0收藏
- 作者：Bao-Li Li Fang Xiao Wen-Chao Lu Yu-Yun Sun Jin Zhu Jian Li
- 机构：Shanghai Key Laboratory of New Drug Design;Department of Pharmacy;China Resources Double-Crane Pharmaceutical Co.
- 来源：中国化学快报（英文版） 2014
- 关键词：Cycloalkyl[d]pyrimidine derivatives FGFR-1 Activator Chemical probe
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- 用氧化烯胺催化的方法从饱和的醛来高效制备反式烯醛(英文)被引量：0收藏
- 作者：张士磊 谢贺新 宋爱国 吴德燕 朱进 赵思涵 李剑 虞心红 王卫
- 机构：Department of Chemistry&Chemical Biology;华东理工大学药学院
- 来源：《中国科学：化学》 2012
- 关键词：醛 烯醛 烯胺 IBX 氧化烯胺催化
- 摘要：本文报道一种温和、高效的胺催化,用IBX作为氧化剂,简单的醛为原料,高产率、高(E)-选择性的制备α,β-不饱和醛.该反应涉及到一种新型的催化氧化烯胺到α,β-不饱和亚胺离子的转换过程.
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