成果/Result
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Negatively charged phospholipids accelerate the membrane fusion activity of the plant-specific insert domain of an aspartic protease被引量：53收藏
- 作者：Zhao, Xiaoli Ma, Xiaomin Dupius, John H. Qi, Ruxi Tian, Jenny Chen, Jiaxin Ou, Xiuyuan Qian, Zhaohui Liang, Dehai Wang, Peiyi Yada, Rickey Y. Wang, Shenlin
- 机构： College of chemistry and molecular engineering; State Key Laboratory of Bioreactor Engineering; Cryo-EM center; Food Nutrition and Health Program; MOH Key Laboratory
- 来源：Journal of Biological Chemistry 2022
- 关键词：Phospholipids - Plants (botany) - Nuclear magnetic resonance spectroscopy - Cell membranes - Liposomes
- A random fractional 13C labeling strategy for P. pastoris expressed eukaryotic membrane protEIns for solid-state NMR studies被引量：44收藏
- 作者：Sang, Meihui Fan, Zejun Ren, Qiongqiong Liu, Jing Zhao, Shaokai Wang, Shenlin
- 机构： State Key Laboratory of Bioreactor Engineering; College of Chemistry and Chemical Engineering
- 来源：Magnetic Resonance Letters 2025
- 关键词：Biological membranes - Cost effectiveness - Light polarization - Nuclear magnetic resonance spectroscopy - ProtEIns - Sanitary sewers - Sodium compounds - Spectral resolution
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：36收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构： State Key Laboratory of Bioreactor Engineering; iHuman Institute; School of Life Sciences and Biotechnology; Department of Chemistry; Program of Chemistry
- 来源：Catalysis Science and Technology 2024
- 关键词：Biosynthesis - Complexation - Conformations - Nuclear magnetic resonance spectroscopy
- Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization被引量：11收藏
- 作者：Zheng, Wen-Qing Zhu, Xin-Xin Zhu, Zheng Yang, Tairan Zheng, Lifen Pan, Rui Wang, Shenlin Zhang, Lixin Chen, Qi Xu, Jian-He Xie, Yongtao Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2025
- 关键词：biocatalysis desymmetrization reductive amination ancestral imine reductase axially chiral biaryl benzylamine
- Mechanisms of antimicrobial peptides as characterized by solid-state NMR被引量：7收藏
- 作者：Han, Rong Wang, Shenlin
- 机构：Peking Univ;Peking Univ;East China Univ Sci & Technol;Beijing Natl Lab Mol Sci
- 来源：MAGNETIC RESONANCE LETTERS 2022
- 关键词：Antimicrobial peptides (AMP) Solid-state NMR (SSNMR) Sample preparation Antimicrobial mechanisms Whole -cell NMR
- Advances in solid-state NMR methods for studying RNA structures and dynamics被引量：2收藏
- 作者：He, Jinhan Liu, Xiaole Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：MAGNETIC RESONANCE LETTERS 2025
- 关键词：Solid-state NMR RNA Structure Dynamics Pulse sequences
- A strategy for producing isotopically labeled peptides with antimicrobial activity or with short in vivo lifetime in Escherichia coli被引量：1收藏
- 作者：Ren, Qiongqiong Fan, Zejun Han, Rong Sang, Meihui Ma, Changxing Zhao, Xiaoli Wang, Shenlin
- 机构：East China Univ Sci & Technol;Peking Univ;Peking Univ;Shandong Polytech
- 来源：PEPTIDE SCIENCE 2024
- 关键词：antimicrobial peptide fusion expression system fusion peptide isotope labeling NMR
- Production of isotope-labeled nanobody KN035 in Pichia pastoris yields native-like conformation and PD-L1 binding activity comparable to KN035 expressed in mammalian cells被引量：0收藏
- 作者：Ren, Piaoran Jiang, Mengzhen Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：MAGNETIC RESONANCE LETTERS 2026
- 关键词：Pichia pastoris Nanobody Isotope labeling Nuclear magnetic resonance ProtEIn expression
- DNA硫修饰结合蛋白识别序列的表征与拓展促进新型核酸检测技术发展被引量：0收藏
- 作者：帅玉婷 许安安 李甲乙 韩照晰 马蒂尼 段海容 王馨叶 蒋岚 张敬宇 谭高翼 刘雪婷 赵一雷 童垚俊 王申林 贺新义 邓子新 刘光 张立新
- 机构：East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：《Science Bulletin》 2023
- 关键词：核酸检测技术 限制性核酸内切酶 SBD 序列模式 识别序列 防御系统 硫原子 抗氧化应激
- 摘要：DNA硫修饰是一种DNA磷酸骨架上的非桥接氧原子被硫原子所取代的修饰,属于原核生物表观遗传标志物之一,它对细菌防御系统、抗氧化应激和基因调控等生命过程具有重要影响.DNA硫修饰可以被硫修饰依赖限制性核酸内切酶的硫结合域S...
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